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Genetics Lab
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A lab that explores the body's homeostasis and disease through the ability of cells to change their properties.
AboutAbout the lab
Understanding how living systems are maintained and how they break down, through cellular plasticity.
The Genetics Lab studies "plasticity of cell fate," the ability of cells to change their properties and roles in response to circumstances.
Animal bodies maintain homeostasis while responding to environmental changes such as nutrition, temperature, injury, and inflammation, and plasticity underlies this ability.
Plasticity is essential for an organism's adaptation, but it is also thought to be closely linked to chronic inflammation and to functional changes that accompany aging.
Through comparative studies using fruit flies (Drosophila) and jellyfish, the lab seeks to uncover the common principles of plasticity in living systems.
Key terms
- Cellular plasticity
- The ability of differentiated cells and stem cells to change their properties and roles in response to circumstances
- Homeostasis
- The function by which the body works to keep its state constant even when the environment changes
ResearchResearch themes
The lab aims to understand, at the molecular and cellular levels, how cellular plasticity is regulated in the body and how it changes in the course of progression from a healthy state to a disease state. Focusing mainly on epithelial tissues, the lab analyzes changes in cell state that occur during development, regeneration, and aging, and in response to the environment.
*Illustrative imageCellular plasticity and homeostasis
The plasticity of cell fate, in which differentiated cells and stem cells change their properties in response to circumstances, is the foundation that allows the structure and function of tissues and organs to be remodeled as the environment changes. The lab investigates how this is regulated in the body.
*Illustrative imageCells in development, regeneration, and aging
Focusing mainly on epithelial tissues, the lab analyzes changes in cell state that occur during development, regeneration, and aging, and in response to the environment. By comparing disease models of neuroinflammation with healthy states and the aging process, the lab aims to identify where functional failure begins.
*Illustrative imageCommunication between organs
The lab focuses on inter-organ communication among the intestine, the nervous system, the immune system, and other organs. It aims to gain an integrated understanding of how a change that occurs in one place affects whole-body homeostasis and the onset of disease.
*Illustrative imageComparison across diverse organisms
In addition to fruit flies, which have a rich set of genetic tools, the lab conducts comparative studies using animals such as jellyfish, which have high regenerative capacity and plasticity, in order to uncover the common principles of plasticity in living systems.
MembersFaculty
- Associate ProfessorYuichiro NakajimaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Drosophila melanogaster under microscope” Talita Oliveira / CC BY-SA 4.0 (cropped)
- Cellular plasticity and homeostasis: “Cell turnover and proliferation in the intestinal epithelium” Cancedda R and Mastrogiacomo M / CC BY 4.0 (cropped)
- Cells in development, regeneration, and aging: “Clytia hemisphaerica day2 planula” Tsuyoshi Momose / CC BY-SA 4.0 (cropped)
- Communication between organs: “Gut-brain-microbiome axis” U3239091 / CC0 (cropped)
- Comparison across diverse organisms: “Clytia hemisphaerica polyp colony” Tsuyoshi Momose / CC BY-SA 4.0 (cropped)
- Related lab (生理化学教室): “Mitotic LLC-PK1 cells, fluorescence microscopy ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Related lab (生命物理化学教室): “NMR Spectrometer” Mgianino / CC BY 3.0 (cropped)
- Related lab (蛋白質代謝学教室): “Proteasome (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (分子生物学教室): “Neural Stem Cells” Welcome Collection / CC BY-SA 4.0 (cropped)
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