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Microbiology and Immunology Lab
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The lab explores how the gut microbiota interacts with host immunity.
AboutAbout the lab
How gut bacteria are linked to immunity
The Microbiology and Immunology Lab, part of the Immunology Group at the Immunology Frontier Research Center, studies how the gut microbiota interacts with host immunity in diseases such as inflammatory bowel disease (IBD), gastrointestinal infections, and colorectal cancer.
Among resident microbes, the lab focuses on the mechanisms by which so-called pathogens cause or worsen disease, and the mechanisms by which beneficial microbes cooperate with host immunity to fight pathogenic microorganisms in the gastrointestinal tract.
The lab also studies the role of diet in regulating the competition between pathogenic bacteria and beneficial bacteria, and the effects of nutrients in the diet on host immunity.
Key terms
- Gut microbiota
- The community of microorganisms in the gut. It includes both so-called pathogens and resident beneficial microbes
- Host immunity
- The immune functions of the organism (the host) in which microbes reside
- Inflammatory bowel disease
- A disease abbreviated as IBD. Along with gastrointestinal infections and colorectal cancer, it is a disease in which this lab studies the link to the gut microbiota
ResearchResearch themes
The lab aims to answer the fundamental question, "How does the gut microbiota interact with host immunity?" Focusing on diseases such as inflammatory bowel disease, gastrointestinal infections, and colorectal cancer, it investigates how pathogens, beneficial microbes, and diet are linked to host immunity.
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MembersFaculty
- ProfessorNobuhiko Kamada
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Inflammed mucous layer of the intestinal villi depicting Celiac disease” www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Interaction between the gut microbiota and host immunity: “Histology of subepithelial lymphoid aggregate of the colon” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Mucosal Immunology Lab): “Culture Plates” Katherine Stember / CC BY 4.0 (cropped)
- Related lab (Cutaneous Allergy and Host Defense Lab): “Staphylococcus aureus 01” Photo Credit: Janice Carr Content Providers(s): CDC/ Matthew J. Arduino, DRPH; Janice Carr / Public domain (cropped)
- Related lab (Molecular Neuroscience Lab): “Nervous Tissue Spinal Cord Motor Neuron ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Related lab (Tissue Immunology of Infection Lab): “Infectiology - Herpes virus 1 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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