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Mucosal Immunology Lab
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A lab that investigates the pathology of inflammatory bowel disease through intestinal immunity and the gut environment.
AboutAbout the lab
Elucidating the causes and pathology of intractable immune diseases
The Mucosal Immunology Lab studies the mechanisms of intestinal immunity, targeting inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
Inflammatory bowel disease is thought to develop when abnormalities of the immune system combine with abnormalities of the intestinal environment.
The lab therefore analyzes the immune system, intestinal environmental factors, and the function of the epithelial layer that separates the two.
On the lab's website, it is introduced under the name "Immunoregulation."
Key terms
- Inflammatory bowel disease
- Intractable diseases of the intestine, typified by Crohn's disease and ulcerative colitis
- Intestinal environmental factors
- Elements that make up the environment inside the intestine, such as gut bacteria and dietary components
- Epithelial layer
- The layer of epithelial cells in the intestine that separates the immune system from intestinal environmental factors
NewsLab news
A review by Associate Professor Mari Murakami is published in Int Immunol
A paper by Associate Professor Hisako Kayama and colleagues is published in Int Immunol
A review by Associate Professor Mari Murakami is published in Immunol Cell Biol
An undergraduate student receives the Yamamura Prize upon graduation
A review by Associate Professor Hisako Kayama is published
ResearchResearch themes
Driven by the aim of making it possible to control intractable immune diseases that current medical technology cannot cure, this lab focuses especially on inflammatory bowel disease. Inflammatory bowel disease is thought to develop when abnormalities of the immune system combine with abnormalities of the intestinal environment, and the lab analyzes the immune system, intestinal environmental factors, and the function of the epithelial layer that separates the two.
*Illustrative imageInnate immune cells in the intestinal mucosa
The lab has identified CD70-positive dendritic cells and regulatory myeloid cells as innate immune cells specific to the intestinal mucosa, and has shown that they play an important role in controlling intestinal immunity. It is investigating how the activity of these cells is controlled and how abnormalities in them are linked to intestinal inflammation.
*Illustrative imageControl of immunity by intestinal environmental factors
Using germ-free mice and mice fed diets of various compositions, the lab analyzes how intestinal environmental factors such as gut bacteria and dietary components control the immune system of the intestinal mucosa. It has found that bacteria-derived ATP and diet-derived vitamin B9, branched-chain amino acids, and bile acids are deeply involved.
*Illustrative imageBarrier function of the intestinal epithelial layer
Using a variety of knockout mice, the lab analyzes the function that maintains the barrier of the epithelial cell layer, which forms the boundary between the immune system and intestinal environmental factors in the gut. It aims to clarify how abnormalities in this function lead to intestinal inflammation.
MembersFaculty
The members of the Mucosal Immunology Lab consist of faculty, project researchers, visiting faculty, project technical staff, administrative staff, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorKiyoshi Takeda
- Associate ProfessorHisako Kayama
- Associate ProfessorDiez Diego
- Associate ProfessorMari Murakami
- Assistant ProfessorRyu Okumura
- Assistant ProfessorEri Igashira
- Assistant ProfessorTakaki Ito
- Project Assistant ProfessorYuji Yamamoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Culture Plates” Katherine Stember / CC BY 4.0 (cropped)
- Innate immune cells in the intestinal mucosa: “Intestinal Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Control of immunity by intestinal environmental factors: “Cross-section histology of small intestinal villi of the terminal ileum” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Barrier function of the intestinal epithelial layer: “Tight junction 03” Kuebi = Armin Kübelbeck / CC BY 3.0 (cropped)
- Related lab (Cutaneous Immunology Lab): “Immunofluorescence light microscopy I” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (Microbiology and Immunology Lab): “Inflammed mucous layer of the intestinal villi depicting Celiac disease” www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Related lab (Cutaneous Allergy and Host Defense Lab): “Staphylococcus aureus 01” Photo Credit: Janice Carr Content Providers(s): CDC/ Matthew J. Arduino, DRPH; Janice Carr / Public domain (cropped)
- Related lab (Experimental Immunology Lab): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped)
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