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Cellular Immunotherapy Lab
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The lab identifies markers of blood cancers and develops CAR-T cell therapies that target them.
AboutAbout the lab
Finding blood cancer markers and targeting them with CAR-T cells
The Cellular Immunotherapy Lab identifies cell surface antigens that are specifically expressed on blood cancers, and carries out the full process of developing CAR-T cell therapies that target them.
The lab has succeeded in developing a new CAR-T cell for multiple myeloma. It is now identifying new target antigens and developing CAR-T cells for acute myeloid leukemia and various solid tumors as well.
The lab has also begun developing CAR-NK cells as an allogeneic cell therapy.
The lab's website is a page of the Department of Hematology and Oncology, where it is introduced as the Cellular Immunotherapy Development Research Group.
Key terms
- Cell surface antigen
- A molecule on the surface of a cell. Those that appear specifically on blood cancer cells are used as targets for CAR-T cells
- CAR-T cell therapy
- A treatment method in which T cells are given an artificial receptor (CAR) that recognizes a target antigen on cancer cells
- Allogeneic
- Derived from the cells of another person, rather than from the patient receiving the treatment
ResearchResearch themes
The lab consistently carries out the identification of cell surface antigens specifically expressed on blood cancers and the development of CAR-T cell therapies that target them. It also aims to develop new cell and gene therapies and immunotherapies that apply various immunological findings generated at Osaka University.
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MembersFaculty
- ProfessorNaoki Hosen
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Architektur eines chimären Antigenrezeptors (CAR)” Michels, A., Hartmann, J. & Buchholz, C.J. / CC BY 4.0 (cropped)
- Developing CAR-T cells that target cancer: “Multiple Myeloma” www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Related lab (Immunology and Allergy Lab): “T Lymphocyte known as a T cell - 2231” NIAID / CC BY 2.0 (cropped)
- Related lab (Signal Transduction Lab): “Bovine Pulmonary Artery Endothelial Cells Fluorescent Image” Erin Rod / CC BY 4.0 (cropped)
- Related lab (Cutaneous Immunology Lab): “Immunofluorescence light microscopy I” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (Immunochemistry Lab): “Westgate Microscopy t-lymphocytes” Cannons Law Firm, Glasgow, UK / CC BY 4.0 (cropped)
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