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Molecular Kinetics Analysis Lab
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A lab that develops PET agents, using radioactive labels to image the movement of molecules inside the body.
AboutAbout the lab
Making molecules inside the body visible with PET.
The Molecular Kinetics Analysis Lab, as the Nuclear Pharmacy Division of the Center for Advanced Quantum Beam Science, studies the use in the life sciences of radionuclides produced by a cyclotron.
The lab aims to use PET imaging, which employs short-lived positron-emitting nuclides, in medical diagnosis and drug discovery research.
Based on basic research on the design and synthesis of labeled compounds, the lab works on developing new diagnostic probes for PET and evaluating them with small-animal PET.
As a cooperating division of the Department of Pharmaceutical Life Sciences in the Graduate School of Pharmaceutical Sciences, the lab accepts undergraduate and graduate students in pharmacy.
Key terms
- PET
- Positron emission tomography. A method that captures the signals emitted from a radioactive label introduced into the body and turns the inside of the body into an image.
- Cyclotron
- A device that accelerates particles in a circular path. In this lab, it is used to produce radionuclides.
- Positron-emitting nuclide
- A radioactive atom that emits positrons. It has a short lifetime and is used as a label when imaging with PET.
ResearchResearch themes
The lab studies PET imaging, which uses compounds labeled with positron-emitting nuclides to capture the movement of molecules inside the body as images. Based on basic research on labeling methods, the lab develops new diagnostic probes and examines their usefulness with small-animal PET.
*Illustrative imageDesign and synthesis of PET probes
The lab studies from the fundamentals the design theory and synthesis methods for labeling compounds with positron-emitting nuclides such as ¹¹C, ¹⁸F, and ¹²⁴I. On this basis, it develops new diagnostic probes for PET and evaluates their usefulness with small-animal PET.
*Illustrative imageDevelopment of PET diagnostic agents and labeling synthesis
The lab develops imaging agents for cancer and Alzheimer's disease, probes that target mitochondria (applied to the diagnosis of myocardial blood flow and brown adipose tissue), and methods for labeling proteins and antibodies. It also works on pharmacokinetic analysis by PET, studies of the pharmacological effects of drugs, and the development of automated synthesis devices and labeling synthesis using microreactors.
MembersFaculty
The members of the Nuclear Pharmacy Division consist of faculty, research professors, academic researchers, research fellows, and technical assistants.
- ProfessorShozo Furumoto
- LecturerYoshihito Funaki
- Assistant ProfessorTakayuki Sakai
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “RIKENSecondCyclotron” Yoshio Nishina / CC0 (cropped)
- Design and synthesis of PET probes: “Radiochemistry Laboratory and Internal Dose Assessment and the International Atomic Energy Agency (ISEA) - Urine Samples (02910131a)” IAEA Imagebank / CC BY 2.0 (cropped)
- Development of PET diagnostic agents and labeling synthesis: “PET-CT-Philips” Partynia / CC BY-SA 4.0 (cropped)
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