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610 labs · 150 student voices
Yatsunami Rie, Associate Professor
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The Yatsunami Lab studies how to enhance the function of enzymes produced by extremophiles through protein engineering. The lab also works on producing useful substances through metabolic engineering of extremophiles. Its main subjects are the extremely halophilic archaeon known in Japanese as "sankaku-kin" (the "triangle microbe"), which has the odd shape of a flat triangular plate, along with alkaliphilic bacteria and thermophiles. Microorganisms from extreme environments have special abilities that ordinary microorganisms lack, such as enzymes that work well under alkaline conditions.
Mie Shimojima, Associate Professor
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The Shimojima Lab studies how plants and algae synthesize and metabolize lipids, and what these lipids do. Lipids not only store energy but also form biological membranes and play a role in transmitting signals. The lab examines how plants change their lipids in response to environmental conditions such as temperature, drought, and nutrient deficiency. Drawing on this knowledge, it also aims to build systems that let plants and algae produce large amounts of useful lipids.
Satoshi Murakami, Professor
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The Murakami Lab studies the three-dimensional structures of proteins using X-ray crystallography to understand how they function. Although proteins are built from combinations of just 20 amino acids, they carry out complex functions. The lab focuses mainly on membrane proteins, which sit in the cell membrane and handle the exchange of substances and information. To tackle targets that are hard to analyze, the lab also refines its techniques for producing, purifying, and crystallizing proteins.
Hata Takeshi, Associate Professor
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The Hata Lab develops new synthetic methods to synthesize and transform organic molecules exactly as desired. Using these methods, the lab synthesizes molecules with diverse functions, such as natural organic compounds and artificial pharmaceuticals. It emphasizes making them efficiently in few steps, and using safe reagents to reduce unnecessary waste. The lab aims to contribute to next-generation "manufacturing" that is essential for a sustainable society.
Kohji Seio, Professor
0 student voices
The Seio Lab uses synthetic organic chemistry to develop functional molecules whose nucleic acid chemical structures have been modified. Nucleic acid therapeutics, which use chemically synthesized nucleic acids as drugs, are attracting attention, and the lab works to improve this technology. The lab designs chemical modifications that improve binding to target RNA and resistance to degradation. It also works on making nucleotide signaling molecules and tools for studying the functions of nucleic acids.
Takafumi Ueno, Professor
0 student voices
The Ueno Lab studies how to use chemistry to functionalize the assemblies formed when proteins gather spontaneously. Protein assemblies are used as functional materials in many places in nature. The lab investigates in detail how they are formed and what their structures are, and, incorporating computational design, creates new biomaterials. These efforts have yielded precisely moving molecular machines, artificial enzymes that surpass natural ones, and molecular cages that store target proteins.
Tomoko Matsuda, Associate Professor
0 student voices
The Matsuda Lab aims to make organic synthesis environmentally friendly, and develops reactions that use enzymes as catalysts. Organic synthesis is an essential method for making pharmaceuticals and agrochemicals, and catalysts are indispensable to it. The lab also studies ways to put carbon dioxide and atmospheric oxygen to effective use as reaction solvents and reactants. Its goal is to develop safe reactions that advance the chemical industry while protecting the global environment.
Eiry Kobatake, Professor
0 student voices
The Kobatake-Mie Lab improves existing proteins and designs new ones to create materials with functions that go beyond those found in nature. Among biomolecules, proteins are the most diverse and perform the most sophisticated functions. The lab calls this approach "super-biofunctional materials engineering," and its main aims are controlling cell functions and biosensing. Using genetic engineering and protein engineering, the lab works on everything from designing materials to verifying how they function.
Shun-Ichiro Ogura, Associate Professor
0 student voices
The Ogura Lab conducts research on 5-aminolevulinic acid (ALA), a safe, naturally occurring substance derived from living organisms. When ALA is administered to cancer cells, a substance that emits red fluorescence accumulates in the cancer. Taking advantage of this property, the lab conducts basic research on a method of diagnosing cancer and on photodynamic therapy, which kills cancer cells by shining light on them. The lab also investigates the various physiological effects of ALA on the body, aiming to contribute to medical applications.
Yamaguchi Yuki, Professor
0 student voices
The Yamaguchi Lab studies how information in the genome is read out. Using cutting-edge methods in biochemistry, genetics, genomics, and proteomics, the lab explores the fundamental truths of basic life science. The lab also works on chemical biology, which investigates how living organisms work using small-molecule compounds as clues. It also actively pursues applied research in medicine and pharmacy, especially research that could lead to the development of new drugs.
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