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Yamaguchi Lab
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The lab uncovers how information in the genome is read out, with the aim of leading to drug discovery.
AboutAbout the lab
Thoroughly elucidating the mechanisms of life and aiming for applied development
The Yamaguchi Lab studies how information in the genome is read out.
Using cutting-edge methods in biochemistry, genetics, genomics, and proteomics, the lab explores the fundamental truths of basic life science.
The lab also works on chemical biology, which investigates how living organisms work using small-molecule compounds as clues.
It also actively pursues applied research in medicine and pharmacy, especially research that could lead to the development of new drugs.
Key terms
- Transcription
- The process in which information written in genomic DNA is copied into RNA by RNA polymerase
- RNA polymerase II
- An enzyme that reads the DNA of a gene and synthesizes messenger RNA
- Chemical biology
- An interdisciplinary research field that uses small-molecule compounds as tools to elucidate how living organisms work
NewsLab news
Study uncovers part of how a multiple myeloma drug works; published in an international journal
Paper on the mechanism of alternative polyadenylation published in an international journal
Collaborative study resolving the structure of the RNA polymerase II complex published in an international journal
Collaborative study revealing a new role of a large protein complex published in an international journal
A master's student received the Excellent Poster Award at the Life Science and Technology Course Master's Midterm Presentation
ResearchResearch themes
The lab aims to elucidate the process by which functional RNA is produced from the genome, getting at the fundamental truths of basic life science. It also uses small-molecule compounds as clues to decipher molecular networks in living organisms, and pursues research that leads to drug discovery.
*Illustrative imageThe brakes and accelerator of transcription
The lab focuses on the elongation stage, in which RNA polymerase II reads through a gene. It newly discovered DSIF and NELF, which act as brakes, and has studied how transcription starts moving again through the opposing actions of these factors and P-TEFb, which releases the brake.
*Illustrative imageThe role of transcriptional regulation in the body
The lab investigates how regulation of transcription elongation is involved in the expression of genes that respond rapidly to external stimuli. Collaborative research using zebrafish and Drosophila has shown that it is also important for the development and differentiation of the nervous system.
*Illustrative imageHow diverse RNAs are generated
The diversity of RNAs produced from the same genome in different cells is thought to arise from regulation of the stage at which transcription ends. The lab is studying how three pathways that process the 3' end of RNA are used selectively, and identifying and analyzing the factors involved in that selection.
*Illustrative imageFishing out targets with FG beads
The lab developed FG beads, microparticles with a magnetic iron core. When a small-molecule compound of interest is immobilized on the beads, the target proteins that bind to that compound can be purified in a single step and in a short time.
MembersFaculty
The members of the Yamaguchi Lab are faculty, master's students, and undergraduate students.As of 2026
- ProfessorYamaguchi YukiPublications ↗
- Assistant ProfessorSakamoto SatoshiPublications ↗
- Assistant ProfessorJunichi YamamotoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DAPI-stained nuclei of HeLa cells” DrBib / CC BY 4.0 (cropped)
- The brakes and accelerator of transcription: “Alpha-Amanitin–RNA polymerase II complex 1K83” Fvasconcellos / Public domain (cropped)
- The role of transcriptional regulation in the body: “Zebrafish embryo” Nikita Tsyba in cooperation with Azamat Bashabayev / CC BY-SA 4.0 (cropped)
- How diverse RNAs are generated: “RNA Polymerase” Maria Voigt and PDB-101 / CC BY 4.0 (cropped)
- Fishing out targets with FG beads: “Magnetic Beads Spider” TiberiusRufus / CC BY-SA 4.0 (cropped)
- Related lab (中村・岡田研究室): “Boron neutron capture therapy (bnct) illustration” Pat Kenny (Illustrator) / Public domain (cropped)
- Related lab (上野研究室): “Flu Self Assembly ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (川井研究室): “Fluorescent minerals hg” Hannes Grobe/AWI / CC BY-SA 2.5 (cropped)
- Related lab (野澤研究室): “Model of Nucleosome Array” Rkott / CC BY-SA 4.0 (cropped)
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