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Kobatake-Mie Lab
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The lab designs proteins to create materials and sensors that control cells.
AboutAbout the lab
Creating biomaterials that go beyond nature.
The Kobatake-Mie Lab improves existing proteins and designs new ones to create materials with functions that go beyond those found in nature.
Among biomolecules, proteins are the most diverse and perform the most sophisticated functions.
The lab calls this approach "super-biofunctional materials engineering," and its main aims are controlling cell functions and biosensing.
Using genetic engineering and protein engineering, the lab works on everything from designing materials to verifying how they function.
Key terms
- Apoptosis
- A process by which cells deliberately bring about their own death. It is used to remodel the body and to remove damaged cells
- Genetic engineering
- Technology that manipulates genes so that cells produce proteins with desired functions
- Biosensing
- A mechanism that detects substances by using the ability of biomolecules to recognize their targets
ResearchResearch themes
The lab works on "super-biofunctional materials engineering," which improves, modifies, or newly designs biomolecules such as proteins to create molecules that go beyond the functions of natural organisms. It has two main aims: controlling cell functions and biosensing.
*Illustrative imageProtein materials that control cell functions
The lab creates new proteins that can control cell behaviors such as adhesion, spreading, proliferation, differentiation, and apoptosis, and is exploring their use in cell engineering, tissue engineering, regenerative medicine, and drug delivery. It also develops new genetic engineering-based methodologies, such as methods for synthesizing protein units and for constructing nanostructures.
*Illustrative imageProtein materials for biosensing
Advanced biosensing can be achieved by using the excellent molecular recognition of biomolecules. Making full use of genetic engineering and protein engineering, the lab designs and builds materials based on proteins and DNA, and works on ultrasensitive sensing, molecular imaging inside living cells, and analysis of intermolecular interactions.
MembersFaculty
The Kobatake-Mie Lab consists of faculty members and master's and undergraduate students.As of 2026
- ProfessorEiry KobatakePublications ↗
- Associate ProfessorMie MasayasuPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “1RRX pdb group” Christopher King / CC BY 3.0 (cropped)
- Protein materials that control cell functions: “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
- Protein materials for biosensing: “Fireflies ( )” Bernd Thaller from Graz, Austria / CC BY 2.0 (cropped)
- Related lab (上野研究室): “Flu Self Assembly ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (金原研究室): “Lipid Bilayer” US gov / Public domain (cropped)
- Related lab (藤枝研究室): “Interference Colors from a Thin polymer Film” Tafaltens / CC BY-SA 3.0 (cropped)
- Related lab (北口研究室): “Crystal Jelly ("Aequorea Victoria"), Monterey Bay Aquarium, Monterey, California, USA” Jim G from Silicon Valley, CA, USA / CC BY 2.0 (cropped)
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