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Ishii Lab
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A lab that measures molecular shapes with solid-state NMR to uncover the mechanisms of Alzheimer's disease.
AboutAbout the lab
Seeing life and the world through molecular structure.
The Ishii Lab uses solid-state NMR spectroscopy to study the mechanisms of life phenomena from molecular structure at the atomic level.
A particular focus is determining the structure of amyloid-β protein, which is considered a main cause of Alzheimer's disease.
The lab also develops its own new solid-state NMR methods that improve measurement sensitivity and resolution.
The lab also collaborates with RIKEN and labs overseas, so people interested in physical chemistry or computer science can also make full use of their strengths.
Key terms
- Solid-state NMR spectroscopy
- A method that measures signals emitted by atomic nuclei in a strong magnetic field to determine the molecular structure of samples in their solid form
- Amyloid-β
- A protein that accumulates in the brain and is considered a main cause of Alzheimer-type dementia
- Amyloid fibril
- A long, thin, fibrous structure formed when proteins assemble. It is strongly toxic to nerve cells
NewsLab news
An undergraduate student received an Excellent Presentation Award at the Undergraduate Specific Research Project Presentation
Collaborative research reveals the structure of senile plaques in familial Alzheimer's disease
Collaborative research identifies an RNA structure involved in the transcription of SARS-CoV-2
ResearchResearch themes
The lab uses solid-state NMR spectroscopy to approach the mysteries of life phenomena from molecular structure at the atomic level. By measuring the structures of amyloid proteins, it works to explain in molecular terms how diseases such as Alzheimer's arise, and to find clues for treatment.
*Illustrative imageThe process of Alzheimer's disease onset
Amyloid-β is harmless on its own, but when many molecules assemble and turn into amyloid fibrils, it shows strong neurotoxicity. The lab has studied the three-dimensional structure of these aggregates and how they form, and is now investigating their structure in the brains of patients and the mechanism by which they spread within the brain.
*Illustrative imageIncreasing the sensitivity of solid-state NMR
The low signal sensitivity of solid-state NMR has been a barrier to measuring biological samples such as proteins. With new measurement methods and sample preparation, the lab has improved sensitivity and resolution, making it possible to measure trace amounts of sample, 1/100 to 1/1000 of what was conventionally required.
*Illustrative imageStructural analysis of nanomaterials
Materials with disordered structures that are hard to examine with electron microscopy, such as graphene oxide (oxidized graphene), can be studied by combining solid-state NMR with chemical shift calculations. Inorganic materials such as battery materials are also targets.
MembersFaculty
The Ishii Lab consists of faculty members, researchers, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorYoshitaka IshiiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Solutions of organic substances for NMR analysis” Ryabitskii / CC BY 4.0 (cropped)
- The process of Alzheimer's disease onset: “Histopathology of amyloid plaque in Alzheimer's disease” Mikael Häggström, M.D. / CC0 (cropped)
- Increasing the sensitivity of solid-state NMR: “Nuclear Magnetic Resonance Laboratory” Shandchem from Scotland / CC BY 2.0 (cropped)
- Structural analysis of nanomaterials: “Sample of graphene oxide” Leiem / CC0 (cropped)
- Related lab (Kinbara Lab): “Lipid Bilayer” US gov / Public domain (cropped)
- Related lab (Kitao Lab): “Vmd screenshot” Hwttdz / CC BY-SA 3.0 (cropped)
- Related lab (Ueno Lab): “Flu Self Assembly ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Kobatake-Mie Lab): “1RRX pdb group” Christopher King / CC BY 3.0 (cropped)
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