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74 labs · 17 student voices
Other departments in School of Life Science and Technology ›Faculties at Institute of Science Tokyo ›
Tomoko Matsuda, Associate Professor
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The Matsuda Lab aims to make organic synthesis environmentally friendly, and develops reactions that use enzymes as catalysts. Organic synthesis is an essential method for making pharmaceuticals and agrochemicals, and catalysts are indispensable to it. The lab also studies ways to put carbon dioxide and atmospheric oxygen to effective use as reaction solvents and reactants. Its goal is to develop safe reactions that advance the chemical industry while protecting the global environment.
Eiry Kobatake, Professor
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The Kobatake-Mie Lab improves existing proteins and designs new ones to create materials with functions that go beyond those found in nature. Among biomolecules, proteins are the most diverse and perform the most sophisticated functions. The lab calls this approach "super-biofunctional materials engineering," and its main aims are controlling cell functions and biosensing. Using genetic engineering and protein engineering, the lab works on everything from designing materials to verifying how they function.
Shun-Ichiro Ogura, Associate Professor
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The Ogura Lab conducts research on 5-aminolevulinic acid (ALA), a safe, naturally occurring substance derived from living organisms. When ALA is administered to cancer cells, a substance that emits red fluorescence accumulates in the cancer. Taking advantage of this property, the lab conducts basic research on a method of diagnosing cancer and on photodynamic therapy, which kills cancer cells by shining light on them. The lab also investigates the various physiological effects of ALA on the body, aiming to contribute to medical applications.
Yamaguchi Yuki, Professor
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The Yamaguchi Lab studies how information in the genome is read out. Using cutting-edge methods in biochemistry, genetics, genomics, and proteomics, the lab explores the fundamental truths of basic life science. The lab also works on chemical biology, which investigates how living organisms work using small-molecule compounds as clues. It also actively pursues applied research in medicine and pharmacy, especially research that could lead to the development of new drugs.
Hiroshi Tsutsumi, Associate Professor
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The Tsutsumi Lab conducts research in the chemistry of life using peptide engineering. Centered on peptides, the lab designs and builds supramolecular systems composed of biopolymers such as glycans and proteins. From these systems, it develops research to create biomolecules with new functions. The lab's research keywords are chemical biology, peptide drug discovery, and bioimaging.
Atsushi Kawakami, Associate Professor
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The Kawakami Lab studies how damaged tissues and organs are restored to their original state. In multicellular organisms, many cells are replaced every day, yet tissues and organs are kept constant. This function is called tissue homeostasis. Among vertebrates, fish have an exceptionally high regenerative capacity, and can restore fins and parts of the heart to their original state even after losing them. Using zebrafish, which have a high regenerative capacity, the lab is working to elucidate the molecular and cellular processes through which tissue regeneration occurs.
Masayuki Komada, Professor
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The Komada-Fukushima Lab studies the intracellular signaling of growth factors, which control the activities of animal cells. Ubiquitin, a small protein, is involved in the transmission of these signals in many different ways. When ubiquitin attaches to a partner protein as a tag, the amount and properties of that protein change, and the signal is regulated. Abnormalities in the signals or in the molecular machinery that receives them cause disease, so the lab is also pursuing research that leads to the development of treatments.
Kazushi Kinbara, Professor
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The Kinbara Lab focuses on the structures and functions of biomolecules and develops new substances with functions never seen before. Living organisms are made up of complex functional biomolecules, which show the ultimate form that organic chemistry can reach. Using synthetic organic chemistry as its main tool, the lab creates molecules that transport substances through cell membranes, molecules that make the inside of cells glow so that it can be seen, and more. Since fiscal 2024, the lab has also taken part in the Research Center for Autonomous Systems Materialogy, Institute of Integrated Research.
Hiroshi Iwasaki, Professor
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The Iwasaki Lab studies how homologous recombination, a reaction carried out by cells, works. Homologous recombination not only gives genomes diversity but also plays important roles in DNA repair and in keeping the genome stable. It is also the central mechanism that restarts replication when replication stops because of DNA damage or other causes. The lab uses a wide range of methods, such as molecular genetics, biochemistry, and structural biology, depending on the level at which the target molecules are analyzed.
Toshiaki Kamachi, Professor
0 student voices
The Kamachi Lab conducts research centered on bioinorganic chemistry. Metal ions are involved in many important biological reactions, including respiration, metabolism, nitrogen fixation, photosynthesis, and neurotransmission. Bioinorganic chemistry combines biology and inorganic chemistry to study the metal ions that are essential to these life processes. The lab works on two areas: elucidating the functions of metalloenzymes for practical applications, and elucidating how oxygen behaves inside cells.
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