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Kawakami Lab
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The lab studies how tissues return to their original state, drawing on the high regenerative capacity of fish.
AboutAbout the lab
Learning from the super healing ability of fish
The Kawakami Lab studies how damaged tissues and organs are restored to their original state.
In multicellular organisms, many cells are replaced every day, yet tissues and organs are kept constant. This function is called tissue homeostasis.
Among vertebrates, fish have an exceptionally high regenerative capacity, and can restore fins and parts of the heart to their original state even after losing them.
Using zebrafish, which have a high regenerative capacity, the lab is working to elucidate the molecular and cellular processes through which tissue regeneration occurs.
Key terms
- Tissue homeostasis
- The body's function of keeping tissues and organs in a constant state even as cells are replaced
- Zebrafish
- A small freshwater fish commonly used in experiments. It is small, easy to keep, and has a high regenerative capacity
- Cell lineage
- The path showing which cell a given cell arose from and which cell it became
ResearchResearch themes
The actual mechanisms by which tissues and organs are kept constant, and by which large-scale tissue regeneration occurs, are still largely unexplained. The lab uses zebrafish, which have a high regenerative capacity, to investigate the molecular and cellular processes through which tissue regeneration occurs.
*Illustrative imageSignals that direct regeneration
Using microarrays, next-generation sequencing, and pharmacological analyses, the lab investigates the genes and signals that control the regeneration process. By combining genetically modified zebrafish with cell transplantation, it determines which cells send signals to which cells.
*Illustrative imageWhere regenerating cells come from
Through cell lineage analysis, the lab investigates how the diverse cells in the regenerated part are produced. It labels cells with fluorescent colors for long-term observation, and marks targeted cells and their descendants using recombination of genomic DNA.
*Illustrative imageGenetics of regeneration in larval fish
The lab analyzes the regeneration process in larval fish about 1 mm in body length, just after development has finished. Using the thousands of mutants that have been created in zebrafish, it can examine how a mutation in a given gene affects regeneration.
MembersFaculty
- Associate ProfessorAtsushi KawakamiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Oryzias latipes(Hamamatsu,Shizuoka,Japan,2007)-1” Seotaro / CC BY-SA 3.0 (cropped)
- Signals that direct regeneration: “Adipose fin 01” Tino Strauss / CC BY-SA 3.0 (cropped)
- Where regenerating cells come from: “Striped elegance” Jaydeep Sidhaye / CC BY-SA 4.0 (cropped)
- Genetics of regeneration in larval fish: “Medaka (Oryzias latipes) egg, day 0” Ethmostigmus / CC BY-SA 4.0 (cropped)
- Related lab (Kamiya Lab): “Fluorescence rainbow” Maxim Bilovitskiy / CC BY-SA 4.0 (cropped)
- Related lab (Hayashi Lab): “1D electrophoresis gel with Cy dyes” Jean-Etienne Poirrier / CC BY-SA 2.0 (cropped)
- Related lab (Kume-Shiraki Lab): “Human induced pluripotent stem cell colony ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (Tagawa Lab): “96 well plate” J.N. Eskra / CC BY-SA 4.0 (cropped)
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