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Kamachi Lab
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A lab that uses the power of metal ions to uncover the reactions of life.
AboutAbout the lab
Tracking the metal ions that sustain life.
The Kamachi Lab conducts research centered on bioinorganic chemistry.
Metal ions are involved in many important biological reactions, including respiration, metabolism, nitrogen fixation, photosynthesis, and neurotransmission.
Bioinorganic chemistry combines biology and inorganic chemistry to study the metal ions that are essential to these life processes.
The lab works on two areas: elucidating the functions of metalloenzymes for practical applications, and elucidating how oxygen behaves inside cells.
Key terms
- Bioinorganic chemistry
- A field combining biology and inorganic chemistry that studies the metal ions essential to life processes
- Metalloenzyme
- A protein that contains metal ions and acts as a catalyst for chemical reactions in living organisms
- Phosphorescence
- Light that a substance emits with a slight delay after absorbing light. For some substances, the way it glows changes depending on the amount of oxygen
ResearchResearch themes
The lab conducts research centered on bioinorganic chemistry. It works in two areas: elucidating the functions of metalloenzymes and applying them to the production of useful substances, and elucidating the behavior of oxygen inside cells.
*Illustrative imageMaking Methanol from Methane
Using methane monooxygenase from methanotrophic bacteria, the lab aims to build a reaction system that converts methane, the main component of natural gas, into methanol under mild conditions. It has also built a system that combines this enzyme with plant chloroplasts to synthesize methanol using light energy.
*Illustrative imageRedesigning Cytochrome c3
The lab introduces site-directed mutations into cytochrome c3, an electron transfer protein from sulfate-reducing bacteria, to clarify the electron transfer pathways within the molecule and to give it new functions. The enhanced variants are applied to processes such as hydrogen production from water using light energy.
*Illustrative imageSeeing Oxygen Inside Cells
Cells take up a dye containing platinum ions, and the lab images oxygen concentration inside the cells by detecting the phosphorescence the dye emits. Because the phosphorescence lifetime changes with the amount of oxygen, the lab was able to observe the distribution of oxygen concentration within a single cell.
*Illustrative imageDeveloping New Phosphorescent Dyes
The lab is developing new dyes with even higher performance than the ones currently in use.
MembersFaculty
The members of the Kamachi Lab consist of faculty, researchers, and doctoral, master's, and undergraduate students.As of 2024
- ProfessorToshiaki KamachiPublications ↗
- Assistant ProfessorHidehiro ItoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Carboxyhemoglobin from 1AJ9” Rifleman 82 / CC BY-SA 3.0 (cropped)
- Making Methanol from Methane: “Canadian Pond Weed Leaf Tip” KarlGaff / CC BY 4.0 (cropped)
- Redesigning Cytochrome c3: “Cytochrome c6 Creinhardtii crystal structure” Kerfeld, C.A., Yeates, T.O. / CC BY-SA 4.0 (cropped)
- Seeing Oxygen Inside Cells: “HaCaT Cells Phase Contrast” Accuratelibrarian / CC BY-SA 4.0 (cropped)
- Developing New Phosphorescent Dyes: “Hackmanite - Phosphorescence” Leland Green... / CC BY-SA 2.0 (cropped)
- Related lab (関根研究室): “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
- Related lab (上野研究室): “Flu Self Assembly ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (下嶋研究室): “Arabidopsis thaliana flower” Peggy Greb, U.S. Department of Agriculture / Public domain (cropped)
- Related lab (神谷研究室): “Fluorescence rainbow” Maxim Bilovitskiy / CC BY-SA 4.0 (cropped)
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