Labs in Nagoya University, Institute for Glyco-core Research, Center for Integrated Glycobiology and Biomedical Sciences

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A bioorganic chemistry lab that handles nucleic acids such as mRNA with chemical methods.

The Drug Discovery Molecular Design Lab is led by Professor Hiroshi Abe, a specialist in bioorganic chemistry, and centers its research on nucleic acid chemistry. The lab has published papers examining how the cap structure at the start of mRNA, the poly(A) tail at its end, and chemical modification of nucleosides affect mRNA stability and translation efficiency. It also has recent papers on designs that enhance translation of circular mRNA, lipid nanoparticles that deliver mRNA to cells, and chemical reactions that join DNA. The lab belongs to the Center for Integrated Glyco-Biomedical Research at the Institute for Glyco-core Research (iGCORE), and its graduate program is under the Graduate School of Science.

#Bioorganic chemistry #mRNA #Chemical modification

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分子生理・動態部門（教員 中村 昭範） (introduction coming soon)

Imaging and blood biomarkers of dementia, especially Alzheimer's disease, from a glycan perspective; genome-wide association studies (GWAS) of N-glycome profile changes in brain disorders and diabetes; biomarkers of immune-mediated peripheral neuropathies (CIDP, autoimmune nodopathies, anti-MAG neuropathy) through analysis of autoantibodies, glycans, complement, and nerve injury markers; neuroimmunology, psychiatric epidemiology, meta-analysis, machine learning

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The lab develops drugs and tools, using molecules that bind to sugars as a starting point.

The Bioactive Molecules Lab studies molecules that one organism produces and that affect another organism, focusing mainly on those related to sugars. Through purification and structure determination of molecules, analysis of their mechanisms of action, and structural modification, the lab aims to develop molecules useful for research, medicine, and agriculture. Using natural products that bind to glycans, and glycans themselves, as starting points, the lab works on developing drugs for infectious diseases and dementia, as well as tools for studying glycans. In 2018, the lab changed its name from the Chemistry of Physiologically Active Substances research group to its current name.

#Glycans #Natural products #Bioactive molecules

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The lab aims to elucidate the pathophysiology of psychiatric disorders and develop diagnostic methods and treatments.

The Psychiatry Lab studies the diagnosis, treatment, causes, and pathophysiology of a wide range of mental disorders, including schizophrenia, depression, bipolar disorder, dementia, and autism spectrum disorder. Taking into account the needs of patients and their families, the lab aims to resolve everyday clinical questions and to develop diagnostic methods, treatments, and preventive methods based on an understanding of causes and pathophysiology. The lab takes a comprehensive approach from a bio-psycho-social perspective and places importance on collaboration between clinical research and basic research. Research projects are carried out in the following areas: genomics, psychotherapy, clinical pharmacology and epidemiology, neuropathology and geriatric psychiatry, child psychiatry, imaging, perinatal psychiatry (pregnant and postpartum women), and basic research.

#Genome-wide association study #Pharmacogenetics #iPS cell research

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The lab explores the mechanisms of cancer through the functions of sugars and glycans.

The Cell and Organism Regulation Lab studies the metabolism of monosaccharides and glycans and its relationship to diseases such as cancer. Project Professor Yoichiro Harada studied the mechanism by which mannose, a monosaccharide, affects the metabolism of cancer cells and the effectiveness of anticancer drugs. Project Assistant Professor Kazuya Izumi is working on research that examines, from the perspective of glycosylation, the muscle atrophy of cancer cachexia, in which muscles waste away as a result of cancer. The lab is part of the Center for Integrative Glycomedicine in the Institute for Glyco-core Research.

#Glycans #Mannose metabolism #Cancer cachexia

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A multidisciplinary lab that explores the brain's predictive functions and neurological and psychiatric disorders.

The Osakada Lab studies how the brain processes information from the outside world, learns, and chooses actions. Centered on physiology, anatomy, and pharmacology, the lab pursues multidisciplinary research that combines molecular biology, stem cell biology, imaging, behavioral analysis, and mathematical analysis. Based on these results, the lab aims to elucidate the pathology of neurological, psychiatric, and eye diseases and to develop preventive and therapeutic methods. The lab belongs to the Cellular Pharmacology field of the Graduate School of Pharmaceutical Sciences, and students from the School of Science can also join from the second semester of their third year.

#Neural circuits #Organoids #Predictive coding