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Osakada Lab
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A multidisciplinary lab that explores the brain's predictive functions and neurological and psychiatric disorders.
AboutAbout the lab
Approaching disease mechanisms through the brain's predictive function
The Osakada Lab studies how the brain processes information from the outside world, learns, and chooses actions.
Centered on physiology, anatomy, and pharmacology, the lab pursues multidisciplinary research that combines molecular biology, stem cell biology, imaging, behavioral analysis, and mathematical analysis.
Based on these results, the lab aims to elucidate the pathology of neurological, psychiatric, and eye diseases and to develop preventive and therapeutic methods.
The lab belongs to the Cellular Pharmacology field of the Graduate School of Pharmaceutical Sciences, and students from the School of Science can also join from the second semester of their third year.
Key terms
- Organoid
- A three-dimensional cultured tissue derived from stem cells such as ES cells and iPS cells
- Viral vector
- A virus used to introduce genes into the cells of a living organism. It is made by modifying viruses such as the rabies virus
- Prediction error
- The discrepancy between the brain's prediction and the information about the external environment that comes in from the sensory organs
NewsLab news
A paper from a joint study with the Department of Neurology at Nagoya University has been published in Neuroscience Research
A student's paper has been published in Cell Reports Methods
A paper from the lab has received the NSR Best Paper Award
A paper by Assistant Professor Takeuchi has been published in Science Advances
A student's paper has been published in PNAS
ResearchResearch themes
The lab investigates how the brain processes information from the outside world, learns, and chooses actions, across multiple levels from the molecular level to the whole-organism and behavioral levels. Based on this understanding, it aims to elucidate the pathology of neurological, psychiatric, and eye diseases and to develop preventive and therapeutic methods.
*Illustrative imageThe brain's predictive function and neural circuits
The brain perceives the outside world by correcting the error between its predictions and sensory input. Using virtual reality, the lab examines how prediction and prediction error signals are generated and transmitted in the brain, and views neurological and psychiatric disorders as abnormalities in predictive information processing.
*Illustrative imageBuilding the brain with human neural organoids
Using neural organoids and assembloids made from monkey ES cells and human iPS cells, the lab reconstitutes synaptic transmission, neural circuits, interactions between brain regions, and the development of disease pathology. It aims to analyze the causes of neurological and psychiatric disorders and to create novel therapeutic drugs.
*Illustrative imageTechnology development using viral vectors
The lab works on technologies for gene delivery into living organisms using adeno-associated virus and rabies virus vectors. By modifying viral vectors and building its own systems, it aims to create new technologies that contribute to neuroscience and gene therapy.
*Illustrative imageTechnologies for observing and manipulating cells with light
In joint development with RIKEN, the lab is developing wide-field one-photon microscopes, multifocal-plane two-photon microscopes, a 4D optical pattern stimulation system, and an optical brain-machine interface (BMI) system for whole-brain observation. It aims to build optical systems that contribute to neuroscience and to the treatment of nervous system diseases.
MembersFaculty
The Osakada Lab consists of faculty members, researchers, doctoral and master's students, and secretaries.As of 2026
- ProfessorFumitaka Osakada
- Assistant ProfessorRyosuke Takeuchi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ultrasonic Research Laboratory” Radvino / CC BY-SA 4.0 (cropped)
- The brain's predictive function and neural circuits: “VR headset with smartphone and stereoscopy image” Bert Niehaus / CC BY-SA 4.0 (cropped)
- Building the brain with human neural organoids: “Human Brain Organoid” Nreis1 / CC BY 4.0 (cropped)
- Technology development using viral vectors: “Adeno-associated virus serotype AAV2” Jazzlw / CC BY-SA 4.0 (cropped)
- Technologies for observing and manipulating cells with light: “Microscope à fluorescence (Ifremer )” Olivier Dugornay / CC BY 4.0 (cropped)
- Related lab (Ikeda Lab): “U.S. Naval Medical Research Unit No. 2, Phnom Penh, Cambodia, Feb. 27” NavyMedicine / Public domain (cropped)
- Related lab (Drug Discovery Molecular Design Lab): “Rotavapor” Geni / CC BY-SA 3.0 (cropped)
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