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Drug Discovery Molecular Design Lab
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A bioorganic chemistry lab that handles nucleic acids such as mRNA with chemical methods.
AboutAbout the lab
Research on making mRNA and nucleic acids using chemical methods.
The Drug Discovery Molecular Design Lab is led by Professor Hiroshi Abe, a specialist in bioorganic chemistry, and centers its research on nucleic acid chemistry.
The lab has published papers examining how the cap structure at the start of mRNA, the poly(A) tail at its end, and chemical modification of nucleosides affect mRNA stability and translation efficiency.
It also has recent papers on designs that enhance translation of circular mRNA, lipid nanoparticles that deliver mRNA to cells, and chemical reactions that join DNA.
The lab belongs to the Center for Integrated Glyco-Biomedical Research at the Institute for Glyco-core Research (iGCORE), and its graduate program is under the Graduate School of Science.
Key terms
- mRNA
- RNA that carries the information for making proteins. The papers discuss its use in vaccines and therapeutics.
- Cap structure
- A structure attached to the start of mRNA. The papers examine its relationship with translation efficiency.
- Lipid nanoparticle
- A tiny particle made of lipids. In the papers, it is treated as a carrier that delivers mRNA to cells.
NewsLab news
View More ↗ResearchResearch themes
The lab handles nucleic acids with chemical methods and studies designs that enhance the function of mRNA and other nucleic acids. Its papers present methods that use chemically synthesized mRNA to examine the relationship between structure and function, and show the effects of chemical modification.
View More ↗MembersFaculty
- ProfessorHiroshi Abe
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Rotavapor” Geni / CC BY-SA 3.0 (cropped)
- Related lab (池田 匡志研究室): “U.S. Naval Medical Research Unit No. 2, Phnom Penh, Cambodia, Feb. 27” NavyMedicine / Public domain (cropped)
- Related lab (生物活性分子研究室): “Beta-D-Glucofuranose Molekülbaukasten 9136 (crop)” user:Bin im Garten / CC BY-SA 3.0 (cropped)
- Related lab (小坂田 文隆研究室): “Ultrasonic Research Laboratory” Radvino / CC BY-SA 4.0 (cropped)
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