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Cell and Organism Regulation Lab (Harada)
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The lab explores the mechanisms of cancer through the functions of sugars and glycans.
AboutAbout the lab
Exploring the mechanisms of cancer through sugars and glycans.
The Cell and Organism Regulation Lab studies the metabolism of monosaccharides and glycans and its relationship to diseases such as cancer.
Project Professor Yoichiro Harada studied the mechanism by which mannose, a monosaccharide, affects the metabolism of cancer cells and the effectiveness of anticancer drugs.
Project Assistant Professor Kazuya Izumi is working on research that examines, from the perspective of glycosylation, the muscle atrophy of cancer cachexia, in which muscles waste away as a result of cancer.
The lab is part of the Center for Integrative Glycomedicine in the Institute for Glyco-core Research.
Key terms
- Glycosylation
- One of the major post-translational modifications of proteins, which uses sugars.
- Mannose
- A monosaccharide. In various cultured cancer cells, it enhances the cell-killing effect of the anticancer drug cisplatin.
- Cancer cachexia
- A severe complication of cancer in which skeletal muscle mass continues to decline and bodily function progressively deteriorates.
ResearchResearch themes
The professors in this lab study the metabolism of monosaccharides and glycans and its relationship to diseases such as cancer. Project Professor Harada focuses on mannose metabolism and cancer, and Project Assistant Professor Izumi on cancer cachexia and glycosylation, exploring the possibility of targeting sugars and glycans for treatment.
How mannose enhances anticancer drugs
The lab studied the mechanism by which mannose enhances the effect of the anticancer drug cisplatin, focusing on a related metabolic disorder known as "honeybee syndrome." Using tracer metabolomics, it traced how glutamine is used in the synthesis of nucleotides. This is Project Professor Harada's theme.
*Illustrative imageMuscle atrophy in cancer cachexia and glycosylation
The lab works on research that examines abnormal sugar use in muscle, when skeletal muscle atrophies in cancer cachexia, from the perspective of glycosylation, a protein modification that uses sugars. It aims to evaluate whether sugars and glycosylation could serve as therapeutic targets. This is Project Assistant Professor Izumi's theme.
MembersFaculty
- Project ProfessorYoichiro Harada
- Project Assistant ProfessorKazuya Izumi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Chemotherapy with acral cooling” Jenny Mealing / CC BY 2.0 (cropped)
- Muscle atrophy in cancer cachexia and glycosylation: “Neurogenic atrophy muscle biopsy HE x100” Jensflorian / CC BY-SA 3.0 (cropped)
- Related lab (生物活性分子研究室): “Beta-D-Glucofuranose Molekülbaukasten 9136 (crop)” user:Bin im Garten / CC BY-SA 3.0 (cropped)
- Related lab (池田 匡志研究室): “U.S. Naval Medical Research Unit No. 2, Phnom Penh, Cambodia, Feb. 27” NavyMedicine / Public domain (cropped)
- Related lab (小坂田 文隆研究室): “Ultrasonic Research Laboratory” Radvino / CC BY-SA 4.0 (cropped)
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