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Other departments in Faculty of Pharmaceutical Sciences ›Faculties at Chiba University ›

Tetsuhiro Nemoto, Professor
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The Medicinal Chemistry Lab studies efficient methods of molecular transformation that are useful for synthesizing pharmaceuticals. Using metal catalysts and organocatalysts, the lab develops new ways of forming bonds and new methods of asymmetric synthesis. The lab is also working to shorten synthetic routes, for example through cascade reactions in which multiple reactions occur in succession. Based on the methods it has developed, the lab also works on the total synthesis of biologically active natural products.

Kenzo Kenzo, Professor
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The Synthetic Medicinal Chemistry Lab studies new synthetic chemistry technologies that freely transform biomolecules such as proteins chemically. Organic chemistry has developed as a discipline for making substances in a test tube, but synthetic chemistry that targets peptides, proteins, and cells is still immature. The lab aims to discover new methods of molecular activation that work under the conditions in which biomolecules function (neutral pH, in water, at room temperature), and to chemically modify proteins at will. The research is carried out with a focus on the unique reactivity of molecules the lab designs itself.

Hayato Ishikawa, Professor
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The Natural Products Drug Discovery Chemistry Lab, grounded in organic chemistry, conducts research that searches for natural products, synthesizes them, and connects them to pharmaceuticals. Natural products are organic compounds made by living organisms, and many drugs to date have been discovered among them. Alongside searching nature for new compounds, the lab carries out total synthesis of rare natural products by combining its own original reactions. Since its founding in 1962, the lab has consistently carried out chemical research on plant alkaloids.

Kunikazu Moribe, Professor
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The Pharmaceutical Engineering Lab conducts research to develop effective and safe drug formulations. Based on the concept of "molecular pharmaceutics," the lab investigates the relationship between the molecular state of drugs and excipients within a formulation and the formulation's properties and efficacy. In particular, the lab works on developing formulations that improve the dissolution of poorly water-soluble drugs and on evaluating their properties. International students and doctoral students who are working professionals are also enrolled, and students give presentations in English at lab seminars and academic conferences.

Noritaka Nishida, Professor
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The Pharmaceutical Physical Chemistry Lab studies the three-dimensional structures of proteins and applies the findings to elucidating biological phenomena and to drug discovery. Proteins perform their functions by forming defined three-dimensional structures. By combining physicochemical methods such as nuclear magnetic resonance (NMR), X-ray crystallography, and cryo-electron microscopy, the lab captures how proteins behave in water and inside cells.

Tyuji Hoshino, Associate Professor
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The Theoretical Drug Discovery Lab combines computational science, organic chemistry, and biochemistry to conduct research on developing drugs rationally and efficiently. Drug development is said to have a low success rate and to require a great deal of cost and time. The lab focuses in particular on developing drugs for cancer and infectious diseases, and also works on antibody therapeutics. Its goal is to become a successful example of university-based drug discovery.

Takuya Hashimoto, Project Professor
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The Molecular Functional Chemistry Lab studies how to design and synthesize molecules with new functions and bring out those functions. Targeting everything from small molecules to polymers and biomolecules, the lab makes substrates, catalysts, molecular probes, and organic materials for reactions. The lab is located at RIKEN in Wako, Saitama, and students conduct research here while enrolled in the master's or doctoral program at the Graduate School of Medical and Pharmaceutical Sciences, Chiba University. The lab is run under a cross-appointment arrangement with the Institute for Advanced Academic Research (Graduate School of Pharmaceutical Sciences), Chiba University.

Katsuhiko Yamamoto, Professor
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The Drug Discovery Physical Properties Lab studies new technologies for evaluating the physical properties of pharmaceuticals, and methods for improving those properties. Its research also covers analytical methods and property evaluation methods that contribute to drug manufacturing, as well as the digital technologies related to them. The lab also works on improving adherence, including devices that use property evaluation technologies and non-oral routes of administration. The lab also conducts analytical and physical property research related to regulatory science. It is a collaborative chair in pharmaceutical sciences at the Graduate School of Medical and Pharmaceutical Sciences, and its partner organization is Takeda Pharmaceutical Company.

Mami Yamazaki, Professor
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The Applied Genetic Resources Lab studies, at the molecular level, how plants produce a wide variety of compounds. The lab believes that the importance of plants as a source of pharmaceuticals lies in the diversity of the compounds they produce, that is, their chemical diversity. The lab grew out of a pharmacognosy laboratory, and now studies plants, the raw materials of crude drugs, as living organisms. The lab aims to apply its findings to the sustainable use of plant resources in the future.

Motoyuki Itoh, Professor
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The Biochemistry Lab studies how cells exchange information with one another (cell-cell signaling). It focuses in particular on Notch signaling, which transmits information between neighboring cells and changes the properties of those cells. The lab uses zebrafish, cultured human and mouse cells, and Drosophila as model systems. In Drosophila, it also aims to elucidate how memory declines with aging.
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