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Pharmaceutical Engineering Lab
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The lab studies poorly water-soluble drugs at the molecular level to turn them into highly effective formulations.
AboutAbout the lab
Understanding how drugs work at the molecular level.
The Pharmaceutical Engineering Lab conducts research to develop effective and safe drug formulations.
Based on the concept of "molecular pharmaceutics," the lab investigates the relationship between the molecular state of drugs and excipients within a formulation and the formulation's properties and efficacy.
In particular, the lab works on developing formulations that improve the dissolution of poorly water-soluble drugs and on evaluating their properties.
International students and doctoral students who are working professionals are also enrolled, and students give presentations in English at lab seminars and academic conferences.
Key terms
- Drug formulation
- An active pharmaceutical ingredient combined with excipients and made into a usable form such as a tablet or an injection
- Solid-state NMR
- A method that measures the signals emitted by atomic nuclei in a strong magnetic field to examine the state of molecules in a solid at the atomic level
- Supersaturation
- A state in which a substance is temporarily dissolved in an amount greater than it can normally hold in solution
NewsLab news
A master's student received the Best Poster Presentation Award at the 51st Pharmaceutical Formulation and Drug Delivery Seminar of the Academy of Pharmaceutical Science and Technology, Japan
A student received the Best Presenter Award at the 41st Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan
A doctoral student received the Student Encouragement Award at the Quantum Beam Science Festa 2025
The lab elucidated the mechanism of a polymer solution that changes from a liquid to a gel near body temperature (Journal of Colloid and Interface Science)
Assistant Professor Ueda received the FY2025 Chiba University Advanced Academic Award
ResearchResearch themes
Based on the concept of "molecular pharmaceutics," the lab conducts research to develop effective and safe drug formulations. It examines the molecular state of active ingredients and excipients within a formulation, applies the results to designing better formulations, and develops evaluation methods for this purpose.
*Illustrative imageEvaluating Formulations with Solid-State NMR
The lab uses solid-state NMR to investigate the state of active ingredient and excipient molecules within solid formulations. It clarifies drug-excipient interactions in systems such as amorphous solid dispersions and uses this to predict formulation stability.
*Illustrative imageDeveloping Methods to Characterize Nanoformulations
The lab observes nanoformulations such as liposomes and drug nanocrystals in detail using cryo-TEM and in-liquid AFM, and examines the relationship between their structure and formulation properties. It is also developing suspended-state NMR, a method for analyzing the surface of nanoparticles in suspension.
*Illustrative imageHow Drugs Dissolve in a Supersaturated State
For supersaturating formulations, which improve the absorption of poorly soluble drugs, the lab evaluates behavior such as the phase separation of the drug from water at the molecular level, mainly using NMR-based spectroscopy, and examines how this relates to drug absorption.
MembersFaculty
The members of the Pharmaceutical Engineering Lab consist of faculty, doctoral, master's, and undergraduate students, research students, and administrative assistants.As of 2026
- ProfessorKunikazu Moribe
- Associate ProfessorKenjiro Higashi
- Assistant ProfessorKeisuke Ueda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pharmaceutical Blister Pack” Michiel4 / CC BY-SA 4.0 (cropped)
- Evaluating Formulations with Solid-State NMR: “Nuclear magnetic resonance devices in CAFIA laboratory” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Developing Methods to Characterize Nanoformulations: “AFM-Raman-TERS” AAMonitor96 / CC BY-SA 3.0 (cropped)
- How Drugs Dissolve in a Supersaturated State: “Equipment and glassware” Belikov Maxim / CC BY 4.0 (cropped)
- Related lab (創薬物性): “Concerta tablets in Japan” Zohang Yuriy / CC BY-SA 4.0 (cropped)
- Related lab (薬品物理化学): “TMEM171 Structure Model” Bauma319 / CC BY-SA 4.0 (cropped)
- Related lab (薬物学): “Disposable Pipette Tips in Laboratory Tip Boxes” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (薬化学): “Student in University of Washington chemistry laboratory , ca 1925 (MOHAI 6219)” Webster & Stevens / Public domain (cropped)
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