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Pharmaceutical Physical Chemistry Lab
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The lab captures the dynamic three-dimensional structures of proteins to elucidate biological phenomena and advance drug discovery.
AboutAbout the lab
Understanding life and drugs through proteins in motion.
The Pharmaceutical Physical Chemistry Lab studies the three-dimensional structures of proteins and applies the findings to elucidating biological phenomena and to drug discovery.
Proteins perform their functions by forming defined three-dimensional structures.
By combining physicochemical methods such as nuclear magnetic resonance (NMR), X-ray crystallography, and cryo-electron microscopy, the lab captures how proteins behave in water and inside cells.
Key terms
- Nuclear magnetic resonance (NMR)
- A method that measures the signals emitted by atomic nuclei in a strong magnetic field to examine the shape and motion of molecules
- Cryo-electron microscopy
- A microscopy technique in which a sample is rapidly frozen and observed with an electron beam to determine the three-dimensional structures of proteins and other molecules
- Molecular crowding
- A state in which many different kinds of proteins and other molecules are packed together at high concentrations, as inside a cell
ResearchResearch themes
The lab investigates the three-dimensional structures of proteins using a variety of physicochemical methods, aiming to elucidate biological phenomena and contribute to drug discovery. It studies how proteins move and function in water and inside cells.
*Illustrative imageUncovering Protein Function from Dynamic Structures
Using nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy, the lab uncovers protein function from protein motion and three-dimensional structure. It has shown that the cell adhesion molecule CD44 and the microtubule-binding domain of the motor protein dynein function by switching between multiple conformations.
*Illustrative imageObserving Proteins Inside Cells with NMR
The inside of a cell is a molecularly crowded environment packed with proteins. The lab developed in-cell NMR, a method for observing proteins directly inside cells, and used it to show that the activity of Ras, a protein involved in cancer, is regulated by a different mechanism inside cells than in a test tube.
MembersFaculty
The members of the Pharmaceutical Physical Chemistry Lab consist of faculty, master's and undergraduate students, and a secretary.As of 2024
- ProfessorNoritaka Nishida
- Assistant ProfessorQingci Zhao
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “TMEM171 Structure Model” Bauma319 / CC BY-SA 4.0 (cropped)
- Uncovering Protein Function from Dynamic Structures: “Bacillus anthracis - CapD protein crystal structure” Argonne National Laboratory / CC BY-SA 2.0 (cropped)
- Observing Proteins Inside Cells with NMR: “Solutions of organic substances for NMR analysis” Ryabitskii / CC BY 4.0 (cropped)
- Related lab (理論創薬): “CSIRO ScienceImage 1788 Molecular model of a protein” division, CSIRO / CC BY 3.0 (cropped)
- Related lab (生物薬剤学): “Atenolol tablets (UK)” Whispyhistory / CC BY-SA 4.0 (cropped)
- Related lab (薬品合成化学): “Molecular model of the pre-pore form of a MACPF protein based upon the structure of pneunolysin” Jcwhizz at English Wikipedia / CC BY-SA 3.0 (cropped)
- Related lab (天然物創薬化学): “Picture from an organic chemistry laboratory” Sil.d / CC BY 4.0 (cropped)
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