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Cardiovascular Drug Discovery Lab (Medical and Hygienic Pharmaceutical Sciences)
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A lab that develops drugs to treat diseases, using the functions of blood vessels as a clue.
AboutAbout the lab
From vascular research to groundbreaking new drugs
The Cardiovascular Drug Discovery Lab investigates the mechanisms of vascular function and applies them to the development of drugs to treat diseases.
Blood vessels are not only passageways that carry oxygen and nutrients through the blood, but also control the movement of substances and cells between the blood and organs by changing their permeability.
The lab works on treating inflammatory diseases and infections, delivering drugs to the brain, and restoring fibrotic organs.
Key terms
- Vascular permeability
- The degree to which substances and cells pass through the vessel wall between the blood and organs.
- Blood-brain barrier
- The function by which blood vessels in the brain keep permeability extremely low, protecting the brain from the entry of foreign substances.
- Fibrosis
- A condition in which organs are repeatedly damaged and fibroblasts increase, lowering organ function.
NewsLab news
A student received the Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
Research results on a new technology for safely delivering drugs to the brain were published in JCR
A student received the Student Excellent Presentation Award at the 145th Annual Meeting of the Pharmaceutical Society of Japan
A student received the Young Researcher Encouragement Award of the Osaka University Sawai Memorial Yakuyukai Award
A student received the Poster Award (Excellence Award) at CVMW2024
ResearchResearch themes
The lab aims to propose unprecedented treatments for diseases, with new ideas based on the results of vascular research. It investigates how vascular function differs and changes from organ to organ, and links this to the development of molecules that control it.
*Illustrative imageDeveloping drugs that suppress vascular permeability
In inflammatory diseases and infections, the disease state arises when vascular permeability becomes excessively high. By understanding the mechanisms that regulate permeability and developing molecules that control it, the lab hopes to propose treatments based on a new strategy.
*Illustrative imageTechnology to deliver drugs to the brain
Blood vessels in the brain have extremely low permeability and, as the blood-brain barrier, protect the brain from the entry of foreign substances. However, this also hinders drug delivery, so the lab develops technologies that transiently control this function to promote drug delivery to the brain.
*Illustrative imageRestoring fibrotic organs
When organs are repeatedly damaged by inflammation or other causes, they become fibrotic and almost never heal on their own. Using blood vessels, the lab works on developing curative treatments that restore fibrotic organs to their original state.
MembersFaculty
The Cardiovascular Drug Discovery Lab consists of faculty members, undergraduate students, and administrative assistants.As of 2026
- ProfessorYoshiaki Okada
- Assistant ProfessorKeisuke Shirakura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blood vessels-MIP” Antonino Paolo Di Giovanna / CC BY-SA 4.0 (cropped)
- Developing drugs that suppress vascular permeability: “Blood vessels structure” Vslv / CC BY-SA 4.0 (cropped)
- Technology to deliver drugs to the brain: “Blood vessels brain english” Armin Kübelbeck / CC BY 3.0 (cropped)
- Restoring fibrotic organs: “Bridging fibrosis in rat liver” Durgesh1104 / CC BY-SA 4.0 (cropped)
- Related lab (生体応答制御学分野
（生命薬学領域） ): “Laboratory desk” Goldmund100 / CC BY-SA 3.0 (cropped) - Related lab (定量生命物理化学分野
（化学薬学領域） ): “Orthogonal views of cytoplasmic capping protein superposed onto its homolog CapZ” Martin Kollmar / CC BY-SA 3.0 (cropped) - Related lab (神経薬理学分野
（医療・衛生薬学領域） ): “Muscarinic receptor M2 coupled to protein G - 6OIK” Vcilleros / CC BY-SA 4.0 (cropped) - Related lab (再生適応学分野
（生命薬学領域） ): “Skeletal muscle 400x” Alexander G. Cheroske / CC BY-SA 4.0 (cropped)
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