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Oral Cell Biology Lab
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A lab that explores how cells sense nutrients, starting from autophagy.
AboutAbout the lab
Opening the frontier of oral medical science through cell biology
The Oral Cell Biology Lab conducts research that opens up the field of oral medical science from the perspective of cell biology, including autophagy.
The lab's scope extends from elucidating fundamental principles of life to clinical applications.
The lab studies how cells sense the presence or absence of nutrients, and the mechanism of microautophagy, one type of autophagy.
As a research support branch, the lab is also responsible for maintaining shared equipment and animal facilities, supporting research across the entire Graduate School of Dentistry.
Key terms
- Autophagy
- A phenomenon in which cells break down part of themselves when nutrients run out. It helps cells survive critical situations.
- TORC1
- One of the regulators that sense nutrients such as amino acids inside cells.
- Microautophagy
- A type of autophagy with a mechanism completely different from that of macroautophagy. Research on it is extremely limited.
ResearchResearch themes
From the perspective of cell biology, including autophagy, the lab aims to open the frontier of oral medical science, from elucidating fundamental principles of life to clinical applications. Its research focuses on elucidating how cells sense nutrients and the mechanism of microautophagy.
*Illustrative imageHow cells sense nutrients
Much remains unknown about the specific mechanisms by which cells sense the presence or absence of nutrients. Starting from elucidating how autophagy is regulated, the lab has worked on clarifying how amino acids and other nutrients are sensed by regulators such as TORC1.
*Illustrative imageThe mechanism of microautophagy
Among the types of autophagy is microautophagy, which is completely different from macroautophagy. Research on it is extremely limited, and the lab is working to elucidate its mechanism.
MembersFaculty
The lab's members consist of faculty, doctoral and master's students, and administrative assistants.
- ProfessorTakeshi Noda
- Assistant ProfessorYasuhiro Araki
- Assistant ProfessorLU SHIOU-LING
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Yeast cells and short hyphae in Gram stain” Ajay Kumar Chaurasiya / CC0 (cropped)
- How cells sense nutrients: “Yeast cells in Gram stain” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- The mechanism of microautophagy: “Lysosomes (NIH BioArt 306)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Regenerative Prosthodontics Lab): “Implant retained bridge model” Ian Furst / CC BY-SA 3.0 (cropped)
- Related lab (Tissue and Developmental Biology Lab): “Trilineage hematopoiesis (original)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Preventive Dentistry Lab): “Stock Images Electric Toothbrush” Electric Teeth / CC BY 2.0 (cropped)
- Related lab (Conservative Dentistry Lab): “Preparing Dental Tools for Patient Treatment” Jameswasswa / CC BY-SA 4.0 (cropped)
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