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Preventive Dentistry Lab
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A lab that explores the prevention of periodontal disease through the mechanisms of oral bacteria and gingiva.
AboutAbout the lab
Aiming to improve quality of life through oral health
The Preventive Dentistry Lab conducts research, education, and clinical practice based on preventive dentistry, the science and technology of preventing oral diseases and maintaining oral function.
Its purpose is to contribute to improving people's quality of life (QOL) and extending healthy life expectancy through oral health.
In its research, the lab investigates at the molecular level how oral biofilms that cause periodontal disease become more virulent, and how the barrier function of the inner marginal gingival epithelium is regulated.
Prevention targets not only disease but also the maintenance of oral functions, such as enjoying meals and conversation.
Key terms
- healthy life expectancy
- The period during which a person can live a healthy, independent daily life
- oral biofilm
- A community formed by multiple bacteria gathering in the mouth. Interactions among the bacteria affect how strongly it causes periodontal disease
- inner marginal gingival epithelium
- Epithelium located on the outer side of the periodontal tissue. It has a barrier function provided by tight junction-related proteins
ResearchResearch themes
The Preventive Dentistry Lab aims to contribute to people's quality of life and to extending healthy life expectancy by preventing oral diseases and maintaining oral function. Its research covers oral biofilms that cause periodontal disease, the barrier function of gingival epithelium, the link between periodontal disease and cardiometabolic disease, and functional foods for preventing oral diseases.
*Illustrative imageIncreased Virulence of Oral Biofilms
Using omics technologies centered on metabolomics, the lab focuses on the physical and chemical interactions among the bacteria that make up oral biofilms. It works to clarify the molecular mechanisms by which biofilms that cause periodontal disease become more virulent.
*Illustrative imageMechanisms of Gingival Epithelial Barrier Function
The lab found that the periodontal pathogen Porphyromonas gingivalis degrades barrier proteins in the gingival epithelium, allowing bacterial toxins to enter beneath the epithelium. It also uses molecular and cell biology approaches to study how environmental and host factors in periodontal disease affect barrier function.
*Illustrative imageThe Link Between Periodontal Disease and Cardiometabolic Disease
The lab collaborates with related engineering and medical research institutions on clinical omics studies exploring the link between periodontal disease and cardiometabolic disease. It is also working to capture changes in the mouth and the whole body from biological information contained in saliva, and to use this for disease diagnosis and assessment of disease activity.
*Illustrative imageFunctional Foods That Prevent Oral Disease
The lab studies prebiotics, such as polyphenols and sugar alcohols, that suppress the increase in virulence of oral biofilms and prevent periodontal disease and bad breath.
MembersFaculty
- ProfessorMasae Kuboniwa
- Project ProfessorCHOI Youn hee
- LecturerHiroki Takeuchi
- LecturerAkito Sakanaka
- Assistant ProfessorEriko Nakamura
- Assistant ProfessorKeita Tanigaki
- Project Assistant ProfessorMoe Inoue
- Project Assistant ProfessorMashu Kudo
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Stock Images Electric Toothbrush” Electric Teeth / CC BY 2.0 (cropped)
- Increased Virulence of Oral Biofilms: “DentalPlaque” Bob Blaylock / CC BY-SA 3.0 (cropped)
- Mechanisms of Gingival Epithelial Barrier Function: “Causes of Periodontal Disease ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- The Link Between Periodontal Disease and Cardiometabolic Disease: “Infers group arting health 2018 street art graffiti cardiovascular disease hypertension funded by welcome 5112x4368” James-Alex Matthews, Infers Group / CC BY-SA 4.0 (cropped)
- Functional Foods That Prevent Oral Disease: “Xylitol chewing gum in a blue bowl” Kotivalo / CC0 (cropped)
- Related lab (口腔治療学講座): “Healthy gingiva” Mohamed Hamze / Public domain (cropped)
- Related lab (薬理学講座): “Pipette 0,5 ml nah” Lysippos / CC0 (cropped)
- Related lab (口腔生理学講座): “Dental tool work DVIDS264901” Petty Officer 3rd Class Jake Berenguer / Public domain (cropped)
- Related lab (歯科保存学講座): “Preparing Dental Tools for Patient Treatment” Jameswasswa / CC BY-SA 4.0 (cropped)
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