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Oral and Maxillofacial Oncologic Surgery Lab
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An oral surgery lab that studies diseases of the jaw and oral cavity, with a focus on oral cancer.
AboutAbout the lab
Facing and studying diseases of the jaw and oral cavity
The Oral and Maxillofacial Oncologic Surgery Lab is in charge of oral and maxillofacial surgery, which clarifies the causes of diseases of the jaw and oral cavity and links that knowledge to treatment.
The lab carries out clinical care, education, and research on diseases such as congenital anomalies, jaw deformities, trauma, inflammation, tumors, and mucosal diseases.
In the graduate school, the lab teaches Oral and Maxillofacial Oncology as the main subject and Advanced Oral and Maxillofacial Surgery as the secondary subject, making tumors a priority area for both clinical work and research.
Its research addresses the mechanisms of lymph node metastasis in oral cancer, new molecular targeted therapies, and more.
Key terms
- GATA genes
- Genes whose expression has been reported in various cancer tissues. GATA3 is also used as a diagnostic marker in cancers such as breast cancer
- Lymph node metastasis
- The spread of cancer to the lymph nodes of the neck. In the treatment of oral cancer, its presence or absence has a major effect on prognosis
- Molecular targeted therapy
- Treatment that acts by targeting specific molecules involved in cancer. Antibody drugs are one example
- 3D tissue culture
- A method of culturing cells three-dimensionally to reproduce tissue structures such as epithelium and blood vessels in vitro
NewsLab news
An Associate Professor received the Director's Award of Osaka University Dental Hospital
An Associate Professor received the Excellence Award at the 28th meeting of the Society for Oral and Facial Nerve Function
A department member received the Oral Presentation Award at the 70th General Assembly and Scientific Meeting of the Japanese Society of Oral and Maxillofacial Surgeons
A paper on computer-assisted surgery was published in the International Journal of Clinical Oncology
A department member received the Excellent Presentation Award at the 36th General Assembly and Scientific Meeting of the Japanese Society of Clinical Oral Pathology
ResearchResearch themes
With tumors as a priority area for clinical work and research, the lab pursues research on oral cancer in particular, covering gene function, the mechanisms of metastasis, and new treatments. It also includes joint research with other labs and other institutions.
*Illustrative imageExpression of GATA genes in oral cancer
Expression of GATA genes has been reported in various cancer tissues, but much about its significance remains unclear. The lab analyzes the expression of GATA genes in oral cancer tissue using molecular biology methods.
*Illustrative imageMechanisms of lymph node metastasis in oral cancer
In the treatment of oral cancer, the presence or absence of cervical lymph node metastasis has a major effect on prognosis. Through analyses using animal experiment models, the lab aims to clarify the mechanisms of lymph node metastasis and to develop new treatments.
*Illustrative imageNew molecular targeted therapies for oral cancer
The lab is studying several new target genes, and in particular aims for the clinical application of an antibody drug that targets E-selectin. This work is carried out in collaboration with a lab in the United States.
*Illustrative imageOral cancer research using 3D tissue culture
In joint research with other labs, the lab uses 3D tissue culture models. Cells are cultured three-dimensionally to reproduce tissue structures such as epithelium and blood vessels in vitro, and this is applied to oral cancer research.
MembersFaculty
The members of the Oral and Maxillofacial Oncologic Surgery Lab consist of faculty, clinical staff physicians, graduate students, resident physicians, and administrative assistants.As of 2026
- ProfessorNarikazu Uzawa
- Associate ProfessorKazuhide Matsunaga
- LecturerYoshihiro Morita
- Assistant ProfessorMasakazu Hamada
- Assistant ProfessorAkinori Takeshita
- Assistant ProfessorSatoko Kishimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Circumcision instruments on green cloth in tray - right” Dan Bollinger / CC BY-SA 4.0 (cropped)
- Expression of GATA genes in oral cancer: “Fluorescence microscopy of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- Mechanisms of lymph node metastasis in oral cancer: “Lymph node metastasis of gum cancer (post-surgery) PET-CT 452” Jmarchn / CC0 (cropped)
- New molecular targeted therapies for oral cancer: “Antibody-drug conjugate” Bioconjugator / CC BY-SA 4.0 (cropped)
- Oral cancer research using 3D tissue culture: “Retina Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Oral Physiology Lab): “Dental tool work DVIDS264901” Petty Officer 3rd Class Jake Berenguer / Public domain (cropped)
- Related lab (Biochemistry Lab): “Cartilage from mouse joint” Kevin Mackenzie, University of Aberdeen / CC BY 4.0 (cropped)
- Related lab (Oral and Maxillofacial Surgery Lab): “Dental instruments by Roboz Tech Surgical” RobozTech / CC BY-SA 4.0 (cropped)
- Related lab (Pediatric Dentistry Lab): “Streptococcus mutans Gram” Y tambe / CC BY-SA 3.0 (cropped)
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