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Regeneration-Inducing Medicine Lab
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The lab investigates how stem cells in the body are maintained and activated.
AboutAbout the lab
Pioneering a field of medicine that guides tissue regeneration inside the body
The Regeneration-Inducing Medicine Lab, an endowed chair, studies how tissue stem cells are maintained in the living body and how they are activated when tissue is damaged.
The lab focuses on HMGB1, a protein released from necrotic tissue, which increases mesenchymal stem cells in the blood and promotes tissue regeneration.
Based on findings from basic research, the lab is also developing an agent that increases mesenchymal stem cells in the blood.
The lab's webpage says that people who are interested are welcome to join.
Key terms
- HMGB1
- A protein found inside the cell nucleus. It is released outside the cell from necrotic tissue
- Mesenchymal stem cells
- Stem cells found in bone marrow that also circulate in the blood. They are involved in tissue regeneration
- Epidermolysis bullosa
- A hereditary blistering skin disease. While studying skin regeneration in this disease, the lab discovered the role of HMGB1
ResearchResearch themes
When tissue is damaged, the tissue stem cells in that area are also lost, so the tissue cannot regenerate functionally and is instead replaced by fibrous scar tissue. The lab aims to clarify the mechanisms that maintain and activate tissue stem cells in the living body, and to pioneer a field of medicine that induces regeneration inside the body.
The Role of HMGB1 Discovered in Skin Regeneration
While studying skin regeneration in epidermolysis bullosa, a hereditary blistering skin disease, the lab found that when the blood level of HMGB1 released from necrotic epidermis rises, peripherally circulating mesenchymal stem cells increase. The stem cells gather around the necrotic tissue, and functional tissue regeneration proceeds.
*Illustrative imageThe Roles of HMGB1 at Three Levels
In normal tissue, HMGB1 acts inside the cell nucleus as a protein that binds DNA and regulates gene expression. In necrotic tissue, it is released outside the cells, activates innate immunity, and promotes the removal of the necrotic tissue. The lab regards it as an important protein that maintains homeostasis at three levels: within the nucleus, within tissue, and within the whole body.
*Illustrative imageBasic Research on How Regeneration Is Induced in the Body
The lab investigates the molecular basis of how HMGB1 activates peripherally circulating mesenchymal stem cells and induces tissue regeneration in the body. It is also studying interactions between HMGB1 and tissue stem cells other than bone marrow mesenchymal stem cells, and searching for new substances in the body that act in a similar way.
*Illustrative imageDeveloping an Agent to Increase Mesenchymal Stem Cells in the Blood
Based on findings from basic research, the lab is developing an agent that increases mesenchymal stem cells in the blood, using a peptide of the HMGB1 domain that activates mesenchymal stem cells. For diseases such as cerebral infarction, myocardial infarction, and GVHD, in which intravenous administration of mesenchymal stem cells has been confirmed to be effective, the lab expects that systemic administration of the peptide, which increases stem cells in the blood, will be similarly effective.
MembersFaculty
- Associate Professor, Endowed ChairKotaro Saga
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Dental pulp stem cells. SEM-BSE” Ivan A. Novikov / CC BY-SA 4.0 (cropped)
- The Roles of HMGB1 at Three Levels: “Protein HMGB1 PDB 1aab” Emw / CC BY-SA 3.0 (cropped)
- Basic Research on How Regeneration Is Induced in the Body: “From mesenchymal stem cells to specific connective tissue cell types” Nassari S, Duprez D and Fournier-Thibault C / CC BY 4.0 (cropped)
- Developing an Agent to Increase Mesenchymal Stem Cells in the Blood: “Stem-cell-syringe-ama-regenerative-medicine” [<a href="https://www.amaskincare.com/about/alice-pien-md-medical-director/">Alice Pien, MD</a>] / CC BY-SA 4.0 (cropped)
- Related lab (Applied Stem Cell Medicine Lab): “Cell Culture in a tiny Petri dish” kaibara87 / CC BY 2.0 (cropped)
- Related lab (Gene and Stem Cell Regenerative Therapeutics Lab): “AA01946a” SozvezdieL / CC BY 4.0 (cropped)
- Related lab (Diabetes Pathophysiology and Medical Care Lab): “(20250417) Blood glucose meter 10” Roy Zuo / CC BY-SA 4.0 (cropped)
- Related lab (Metabolism and Vascular Medicine Lab): “Histopathology of coronary artery atherosclerosis, original” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
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