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Metabolism and Vascular Medicine Lab
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This metabolism and vascular medicine lab investigates the path from visceral fat to arteriosclerosis.

AboutAbout the lab
Clarifying the molecules that link visceral fat and arteriosclerosis
The Metabolism and Vascular Medicine Lab is an endowed chair that studies lifestyle-related diseases and arteriosclerosis broadly, from basic medicine to clinical medicine.
Its research rests on the understanding that arteriosclerosis progresses on the basis of abnormalities such as those in blood glucose and blood pressure and ultimately leads to death, and that these abnormalities are mainly due to the accumulation of visceral fat.
The lab discovered adiponectin as a molecule that directly links visceral fat and arteriosclerosis, and has studied its significance and function in humans.
The lab proposed visceral fat syndrome and metabolic syndrome, and aims to clarify the mechanisms by which these conditions arise.
Key terms
- Metabolic syndrome
- A condition in which abnormalities such as high blood glucose, high blood pressure, high triglycerides, or low HDL cholesterol are mainly based on the accumulation of visceral fat
- Adiponectin
- A molecule discovered by this research group as a direct link between visceral fat and arteriosclerosis
- Arteriosclerosis
- A disease that arises and progresses on the basis of abnormalities such as those in blood glucose. When it advances, it ultimately leads to death
ResearchResearch themes
Using visceral fat and arteriosclerosis as keywords, the lab conducts research broadly, from basic medicine to clinical medicine. It aims to clarify the molecular basis of metabolic syndrome, which was proposed by Osaka University, and of adiponectin, which the lab discovered, and to link them to medical applications.
*Illustrative imageMolecules Linking Visceral Fat and Arteriosclerosis
Centered on adiponectin, the lab finds new molecules involved in the onset and progression of metabolic syndrome and studies their functions. It also analyzes the pathology of obese adipose tissue, advancing research that connects basic and clinical science.
*Illustrative imagePathophysiology of Metabolic Syndrome
Japanese patients with diabetes used to be mostly lean, but in recent years the number of patients with obesity has increased rapidly. The lab aims to apply medically the molecular mechanisms of metabolic syndrome that it has clarified through clinical and basic research.
MembersFaculty
- Associate Professor, Endowed ChairYuya Fujishima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Histopathology of coronary artery atherosclerosis, original” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Molecules Linking Visceral Fat and Arteriosclerosis: “Atherosclerosis 2011-es” National Heart Lung and Blood Insitute (NIH) / CC BY 4.0 (cropped)
- Pathophysiology of Metabolic Syndrome: “Fatmouse” The original uploader was Bigplankton at English Wikipedia. Later versions were uploaded by Sunholm at en.wikipedia. / Public domain (cropped)
- Related lab (Obesity and Adipose Tissue Pathophysiology Lab): “Connective Tissue Adipose ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Related lab (Artificial Intelligence in Diagnostic Radiology Lab): “CT Naeotom Alpha Pilsen 2022 (cropped)” Tomáš Vendiš / CC BY-SA 4.0 (cropped)
- Related lab (Clinical Gene Therapy Lab): “AAV Gene Therapy” George Church / CC BY-SA 3.0 (cropped)
- Related lab (Diabetes Pathophysiology and Medical Care Lab): “(20250417) Blood glucose meter 10” Roy Zuo / CC BY-SA 4.0 (cropped)
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