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Applied Stem Cell Medicine Lab
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The lab investigates how stem cells differentiate and are maintained, and develops technologies for treating diseases.
AboutAbout the lab
Unraveling how stem cells work to create new medical technologies
The Applied Stem Cell Medicine Lab studies pluripotent stem cells such as iPS cells and ES cells, as well as mesenchymal stem cells and epithelial stem cells.
The lab aims to clarify the mechanisms of stem cell differentiation and maintenance of the undifferentiated state, and, based on these findings, to develop new medical technologies for curing diseases.
The lab carries out translational research, which develops basic research into practical medical technologies.
Using methods from cell biology, regenerative medicine, molecular biology, and tissue engineering, the lab welcomes students and researchers from a wide range of fields, including medicine, engineering, pharmacy, agriculture, science, and veterinary medicine.
Key terms
- Translational research
- Research that takes results from basic research and connects them to medical technologies that can actually be used
- Organoid
- A cluster of cells grown in culture from stem cells that has a structure resembling an organ or tissue
- Culture supernatant
- The liquid portion that remains after the cells are removed from the medium in which they were cultured
ResearchResearch themes
The lab studies pluripotent stem cells, mesenchymal stem cells, and corneal epithelial stem cells, investigating the biological phenomena involved in differentiation and maintenance of the undifferentiated state. Based on the fundamental findings obtained, the lab works to develop new medical technologies for treating diseases.
*Illustrative imageEye organoids made from iPS cells
The lab has developed a method to generate two-dimensional eye organoids from human iPS cells and ES cells that recapitulate eye development from the posterior segment to the anterior segment. Using corneal epithelial cells taken from these organoids, the lab succeeded in corneal regenerative medicine with iPS cells. It now works to clarify how scaffolds and physical stimuli regulate differentiation, and to develop new regenerative therapies.
*Illustrative imageTherapies using mesenchymal stem cells
The lab found that the culture supernatant of mesenchymal stem cells has an anti-EMT effect on corneal epithelial cells, and that the exosomes it contains promote colony formation by corneal epithelial progenitor cells. These results suggest that the culture supernatant is promising as a new therapeutic agent for diseases.
*Illustrative imageHow corneal epithelial stem cells are maintained
Corneal epithelial stem cells are found specifically in the limbus, the region between the cornea and the conjunctiva, and are widely studied as a model of epithelial stem cells. The lab uses corneal epithelial stem cells to clarify the mechanisms by which stem cells are maintained.
MembersFaculty
The members of the Applied Stem Cell Medicine Lab consist of faculty, joint researchers, staff (including visiting researchers), students in the doctoral, master's, and undergraduate programs, and graduate research students.As of 2021
- Associate Professor, Endowed ChairSusumu Sakimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cell Culture in a tiny Petri dish” kaibara87 / CC BY 2.0 (cropped)
- Eye organoids made from iPS cells: “Retinal Organoid ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Therapies using mesenchymal stem cells: “MSCs D21” MFT29 / CC BY-SA 4.0 (cropped)
- How corneal epithelial stem cells are maintained: “Corneal epithélium” Zhiguo.he / CC BY-SA 4.0 (cropped)
- Related lab (Regeneration-Inducing Medicine Lab): “Dental pulp stem cells. SEM-BSE” Ivan A. Novikov / CC BY-SA 4.0 (cropped)
- Related lab (Obesity and Adipose Tissue Pathophysiology Lab): “Connective Tissue Adipose ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Related lab (Gene and Stem Cell Regenerative Therapeutics Lab): “AA01946a” SozvezdieL / CC BY 4.0 (cropped)
- Related lab (Drug Discovery Neuroscience Lab): “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
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