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Diabetes Pathophysiology and Medical Care Lab
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The lab explores diabetes treatment tailored to each patient.
AboutAbout the lab
Exploring personalized diabetes care based on each patient's pathophysiology
The Diabetes Pathophysiology and Medical Care Lab is an endowed department of the Osaka University Graduate School of Medicine, and aims to provide appropriate diabetes care according to each patient's pathophysiology and comorbidities.
Its main theme is how treatment should be carried out depending on age, serious coexisting diseases, and the pathophysiology of diabetes.
The lab studies how to choose drugs for older patients, treatment of patients who also have cancer, delayed diagnosis and treatment interruption in lifestyle-related diseases, and factors that improve insulin resistance.
Putting patients at the center, the lab sets out to share information on how best to manage diabetes for patients in a variety of situations, as a form of medical science for care.
Key terms
- GLP-1 receptor agonist
- A drug that acts on the receptor for human glucagon-like peptide-1. Its combination with basal insulin is under study
- Medication adherence
- The degree to which patients take their medication as prescribed. The lab is studying ways to improve it
- Insulin resistance
- A state in which insulin does not work well. When inflammation occurs in adipose tissue and elsewhere, insulin action weakens
ResearchResearch themes
In diabetes treatment, glycemic targets are considered to need setting for each patient, taking into account age, duration of illness, degree of vascular complications, and serious comorbidities. The lab pursues research to find which treatments are appropriate for each age, comorbidity, and pathophysiology of diabetes.
*Illustrative imageChoosing diabetes drugs for older adults
In older patients with diabetes, preventing hypoglycemia and simplifying treatment procedures take priority. The lab examines the usefulness of combining basal insulin with GLP-1 receptor agonists, the effect of oral glucose-lowering drugs on treatment satisfaction, and the actual state of medication adherence.
*Illustrative imageTreating diabetes patients who also have cancer
Liver cancer is one of the malignancies that often develop in patients with diabetes. In joint research with gastroenterology, the lab seeks to clarify how differences in glycemic control and the drugs used relate to survival prognosis and recurrence rate in diabetes patients who develop liver cancer.
*Illustrative imageDelayed diagnosis and treatment interruption in lifestyle-related diseases
Targeting patients with cardiovascular disease, including peripheral artery disease, the lab investigates how their lifestyle-related diseases were previously diagnosed and treated, and seeks to clarify how often diagnosis is delayed or treatment is interrupted and which factors are associated with them. The lab also plans to follow these patients to examine the effects on all-cause mortality and the onset of cardiovascular disease.
*Illustrative imageFactors that improve insulin resistance
Reduced insulin sensitivity is one cause of diabetes, and when inflammatory immune cells infiltrate adipose tissue and other tissues and cause inflammation, insulin action weakens. The lab identifies factors that suppress this immune cell infiltration, with the aim of improving obesity-related type 2 diabetes.
MembersFaculty
- Associate Professor, Endowed ChairJunji Kozawa
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “(20250417) Blood glucose meter 10” Roy Zuo / CC BY-SA 4.0 (cropped)
- Choosing diabetes drugs for older adults: “Subcutaneous injection with insulin needle” British Columbia Institute of Technology (BCIT) / CC BY 4.0 (cropped)
- Treating diabetes patients who also have cancer: “Capteur de glycémie pour personnes diabétiques” Celeda / CC BY-SA 4.0 (cropped)
- Delayed diagnosis and treatment interruption in lifestyle-related diseases: “CT Coronary Artery Imaging” Goleisureintl / CC BY 4.0 (cropped)
- Factors that improve insulin resistance: “Giemsa Stain Macrophage Illustration” Noah Smith / CC BY-SA 4.0 (cropped)
- Related lab (Drug Discovery Neuroscience Lab): “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
- Related lab (Regeneration-Inducing Medicine Lab): “Dental pulp stem cells. SEM-BSE” Ivan A. Novikov / CC BY-SA 4.0 (cropped)
- Related lab (Metabolism and Vascular Medicine Lab): “Histopathology of coronary artery atherosclerosis, original” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Visual Function Reconstruction Lab): “EpiretinalMembrane OCT” Jmarchn / CC BY-SA 3.0 (cropped)
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