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Cell Regulation Lab
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The lab aims to develop new vaccines by studying the immunity of T cells that recognize lipids.
AboutAbout the lab
"Lipid immunity": a new approach.
The Cell Regulation Lab studies immunology from a new angle called "lipid immunity."
Unlike conventional T cells that recognize proteins (peptides), there are known to be T cells that recognize lipids and lipid-linked peptides. The lab aims to elucidate the full picture of this new form of immunity and to develop new lipid vaccines.
Regarding the admission of graduate students, prospective applicants are advised to contact the lab.
Key terms
- T cell
- A lymphocyte that recognizes specific markers (antigens), attacks abnormal cells, and regulates immune responses
- MHC
- A molecule on the cell surface that presents molecular fragments to T cells
- Lipopeptide
- A peptide with a lipid attached
ResearchResearch themes
The lab combines immunology, cell and structural biology, and lipid biochemistry, using human cells as well as mice, guinea pigs, and monkeys into which human CD1 genes have been introduced.
*Illustrative imageT Cells That Recognize Lipids
The lab is working to clarify an immune mechanism that recognizes lipids and lipidated peptides, which is barely covered even in textbooks. Its research is motivated by infectious diseases such as tuberculosis and AIDS, as well as cancer and allergic and autoimmune diseases.
*Illustrative imageMHC Presenting Lipopeptides
The lab investigates how MHC class I molecules present lipopeptides, through structural analysis and other approaches. It has reported that lipopeptide-presenting MHC induces a new type of killer T cell response that differs from conventional ones.
MembersFaculty
- Assistant ProfessorDaisuke Morita
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
- T Cells That Recognize Lipids: “Mycobacterium tuberculosis” Photo Credit: Janice Carr Content Providers(s): CDC/ Dr. Ray Butler; Janice Carr / Public domain (cropped)
- MHC Presenting Lipopeptides: “CD4+MHCII 1JL4” own work / Public domain (cropped)
- Related lab (RNAウイルス分野): “Novel Coronavirus SARS-CoV- )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (微細構造ウイルス学分野): “Influenza A Virus (H3N )” NIAID / CC BY 2.0 (cropped)
- Related lab (がんウイルス分野): “HumanPapillomavirus” NIAID / Public domain (cropped)
- Related lab (ウイルス分子病態分野): “Herpesvirus (negative staining)” Dr Graham Beards / CC BY-SA 4.0 (cropped)
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