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Cancer Virology Lab
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The lab explores how cancer develops by studying the interactions between cells and the viruses that cause cervical cancer.
AboutAbout the lab
The mechanisms and control of virus-induced cancer.
The Cancer Virology Lab (Sakai group) studies virus–cell interactions in detail, aiming to elucidate how viral infection causes cancer and to develop ways to control it.
Its main research subject is human papillomavirus, which causes cervical cancer.
Regarding the admission of graduate students, prospective applicants are advised to contact the lab.
Key terms
- Human papillomavirus
- A virus that causes warts, cervical cancer, and other diseases
- Wnt signaling
- A cell-to-cell signaling pathway important in development and body patterning; abnormalities in it can lead to cancer
ResearchResearch themes
The lab studies two topics: tumor formation by papillomavirus and Wnt signaling.
*Illustrative imagePapillomavirus Infection and Tumor Formation
Papillomavirus infection causes not only benign tumors such as warts but also malignant tumors such as cervical cancer. The lab investigates this viral infection and how it leads to tumor formation.
*Illustrative imageWnt Signaling
Intracellular signal transmission by Wnt plays an important role in development and morphogenesis, and mutations in genes of this pathway cause many cancers. The lab analyzes the Wnt signaling pathway in vitro and in vivo.
MembersFaculty
- Associate ProfessorHiroyuki Sakai
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “HumanPapillomavirus” NIAID / Public domain (cropped)
- Papillomavirus Infection and Tumor Formation: “Colorized electron micrograph of HPV virus particles (teal)” NIAID / CC BY 2.0 (cropped)
- Wnt Signaling: “Wnt signaling pathway” Srgokribb / CC BY-SA 4.0 (cropped)
- Related lab (RNAウイルス分野): “Novel Coronavirus SARS-CoV- )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (微細構造ウイルス学分野): “Influenza A Virus (H3N )” NIAID / CC BY 2.0 (cropped)
- Related lab (細胞制御分野): “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
- Related lab (ウイルス分子病態分野): “Herpesvirus (negative staining)” Dr Graham Beards / CC BY-SA 4.0 (cropped)
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