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Chemical Biology Lab
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A chemical biology lab that uses original compounds as tools to study and manipulate cells.
AboutAbout the lab
Exploring biology, starting from chemistry.
Chemical biology is biology that starts from chemistry. Life is ultimately made up of chemical reactions, so conversely, chemistry should make it possible to understand and manipulate biological phenomena.
The Chemical Biology Lab, also known as the Uesugi Lab, has been discovering and designing organic compounds that have unique effects on living organisms and human cells, and using them as tools to investigate and manipulate biological phenomena.
Its major goal is to open up a new world of bioactive synthetic compounds. By proposing compounds with new uses, new shapes, and new sizes, the lab aims to contribute to future approaches to drug discovery and to cell therapy.
Key terms
- Chemical biology
- Research that uses chemical compounds as tools to investigate and manipulate the mechanisms of life
- Chemoproteomics
- A method for comprehensively identifying which proteins in a cell a compound binds to
- Self-assembly
- The spontaneous gathering of molecules to form larger structures
- Adjuvant
- A substance used together with a vaccine to enhance its effectiveness
ResearchResearch themes
The lab works on cell biology using synthetic compounds, manipulation of cells, self-assembling bioactive substances, compounds that accelerate cell therapy and immunotherapy, and substances at the boundary between pharmaceuticals and materials.
*Illustrative imageEnhancing anti-cancer immunity with compounds
The lab searches for small molecules that activate immunity against cancer. Using chemoproteomics, it identified proteins that bind spermidine and discovered compounds that enhance cancer immunity.
*Illustrative imageSelf-assembling compounds
The lab has found that small molecules that assemble on their own can take up specific proteins inside cells and can also act as vaccine adjuvants.
MembersFaculty
- ProfessorMotonari Uesugi
- Assistant ProfessorMasahiro Abo
- Assistant ProfessorKosuke Nishio
- Assistant ProfessorSINGH Vaibhav Pal
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Chemical biology flowchart” Bread6 / CC0 (cropped)
- Enhancing anti-cancer immunity with compounds: “Spermidine molecule spacefill” Jynto (talk) / CC0 (cropped)
- Self-assembling compounds: “Molecular Organic Cage Structures” Annyeong24 / CC BY 4.0 (cropped)
- Related lab (Pathogenic Immunology Lab): “T Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Cancer and Stem Cell Signaling Lab): “Illustration of stem cell control by the niche.” Secker, G.A., and Daniels, J.T., Limbal epithelial stem cells of the cornea (June 30, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.48.1, http://www.stembook.org. / CC BY 3.0 (cropped)
- Related lab (Virus Control Lab): “Virus Particle Icon (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Organic Chemistry for Drug Discovery Lab): “Chemical structure of necine bases” Xu, J., Wang, W., Yang, X., Xiong, A., Yang, L., & Wang, Z. / CC BY-SA 4.0 (cropped)
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