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Virus Control Lab
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The lab works out how viruses that threaten children enter cells, and develops drugs and antibodies to block them.
AboutAbout the lab
Starting from how viruses enter cells.
Infectious diseases remain a threat to children around the world. The Division of Virus Control (Hashiguchi Lab) studies viral infectious diseases that affect children.
The lab focuses in particular on clarifying how viruses enter cells and how compounds, peptides, glycans, and antibodies block that entry.
The research combines virology, structural biology, and computer science.
Key terms
- Host factor
- A molecule on the cell side that a virus uses inside the cell it has infected
- Reverse genetics
- A method of artificially assembling genes to create viruses and other organisms and study how they function
- Cryo-electron microscopy
- A technique that rapidly freezes a sample and images it with an electron microscope to determine the three-dimensional structure of molecules
- Paramyxovirus
- A group of viruses that includes those that cause measles and mumps
ResearchResearch themes
The lab aims to clarify how viruses infect cells and replicate, and to apply this to the prevention and treatment of viral diseases.
*Illustrative imageFunction and structure of viral proteins
The lab seeks to reveal both how viruses cause disease and how the human immune system counters them. Function is studied with reverse genetics, and structure with X-ray crystallography and cryo-electron microscopy.
*Illustrative imageHost factors used by viruses
Viruses use host factors at every step of their life cycle. Focusing on paramyxoviruses (measles and mumps) and coronaviruses, the lab identifies these molecules, with the aim of developing drugs that target the sites where viruses bind to host factors.
*Illustrative imageDeveloping methods of prevention and treatment
Based on protein structures, the lab conducts basic research for vaccine development and develops therapeutic antibodies, compounds, and peptides. It puts particular effort into developing new ways of making antibodies.
MembersFaculty
- ProfessorTakao Hashiguchi
- Assistant ProfessorTateki Suzuki
- Assistant ProfessorYuma Sato
- Assistant ProfessorKanako Kimura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Virus Particle Icon (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Function and structure of viral proteins: “Measles virion” Olga V. Matveeva, Svetlana A. Shabalina / CC BY 4.0 (cropped)
- Host factors used by viruses: “3D medical animation coronavirus structure esp” https://www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Developing methods of prevention and treatment: “Flu vaccine vial (2021) A” Prefeitura Campinas / Public domain (cropped)
- Related lab (ケミカルバイオロジー): “Chemical biology flowchart” Bread6 / CC0 (cropped)
- Related lab (生体機能化学): “Zinc finger rendered” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Related lab (京都大学 緒方研究室
（微生物生態学・進化学・バイオインフォマティクス） ): “Cryoelectron microscopy of the Giant Mimivirus - journal.pbio.1000092.g005” Xiao C, Kuznetsov YG, Sun S, Hafenstein SL, Kostyuchenko VA, et al. (2009) / CC BY 2.5 (cropped) - Related lab (がん・幹細胞シグナル学): “Illustration of stem cell control by the niche.” Secker, G.A., and Daniels, J.T., Limbal epithelial stem cells of the cornea (June 30, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.48.1, http://www.stembook.org. / CC BY 3.0 (cropped)
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