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Organelle Informatics Lab
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The lab explores how mitochondria sense changes in their environment and relay that information to the cell.
AboutAbout the lab
How mitochondria sense changes in their environment.
Mitochondria are not only the cell's largest site of energy production but also organelles that carry out diverse functions, including the synthesis of small molecules such as iron-containing cofactors, heat production in the body, cell death, and immune responses.
The lab tackles the fundamental question: "How do mitochondria sense changes in their environment and convert them into cellular responses?"
In particular, the lab focuses on "fluctuations of small molecules in the body" and "mitochondrial stress," combining molecular biology, cell biology, and genetics with comprehensive analyses such as proteomics and metabolomics.
Key terms
- Mitochondria
- Organelles in the cell that produce energy. They also have many other functions
- Organelle
- A small structure within a cell that has a specific function
- Brown adipose tissue
- A fat tissue that produces heat and helps maintain body temperature. It is rich in mitochondria
- Endoplasmic reticulum
- A membrane structure in the cell that produces proteins and lipids
ResearchResearch themes
The lab studies how mitochondria sense environmental changes inside and outside themselves, convert them into intracellular signals, and trigger responses suited to the situation.
*Illustrative imageHow mitochondria sense environmental change
Mitochondria have sensor proteins that detect environmental changes. The lab aims to identify new sensors and to clarify their significance using knockout mice.
*Illustrative imageMitochondria in brown fat
The lab investigates how mitochondrial function is maintained in brown adipose tissue, which generates body heat, and clarifies how it relates to energy metabolism and systemic metabolic regulation.
*Illustrative imageCoordination between organelles
Sites where mitochondria and the endoplasmic reticulum physically contact each other are attracting attention as hubs for small-molecule transport and signal transduction. The lab studies how functions are regulated through coordination between mitochondria and other organelles.
*Illustrative imageBuilding tools to study stress responses
Drawing on its strength of being part of a graduate school of pharmaceutical sciences, the lab aims to develop, from a chemical biology perspective, new experimental tools and analytical systems for precisely analyzing mitochondrial stress responses.
MembersFaculty
- ProfessorShiori Sekine
- Associate ProfessorYusuke Sekine
- Assistant ProfessorHijiri Oshio
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Damaged Mitochondria (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- How mitochondria sense environmental change: “Mitochondrial Fission and Fusion” Rtian96 / CC BY-SA 4.0 (cropped)
- Mitochondria in brown fat: “Hibernoma ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Coordination between organelles: “MERCS Mitochondria-ER contact sites (English)” Tomasknedlik / CC BY-SA 4.0 (cropped)
- Building tools to study stress responses: “Tsien lab fluorescent petri dish” Students and/or staff within the lab of Roger Tsien / CC BY-SA 4.0 (cropped)
- Related lab (多細胞システム学): “Illu epithelium” US Government / Public domain (cropped)
- Related lab (組織形
成動力学): “Drosophila suzukii” Katja Schulz / CC BY 4.0 (cropped) - Related lab (数理治療薬学): “Iodine pills” Mx. Granger / CC0 (cropped)
- Related lab (薬理ゲノミクス・ゲノム創薬科学): “Rasyslami” The original uploader was (Automated conversion) at English Wikipedia. / CC BY-SA 3.0 (cropped)
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