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Mathematical Therapeutics Lab
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The lab uses mathematics and experiments to clarify individual differences in how drugs work and in their side effects.
AboutAbout the lab
Even the same drug works differently from person to person.
Drugs are given to real patients who differ greatly in genetic background, living environment, and health condition. As a result, even drugs whose efficacy and safety have been confirmed in clinical trials may have limited effects, or may cause side effects from drug-drug or drug-food interactions, or unexpected side effects.
The Mathematical Therapeutics division aims to identify the causes of these risks and to establish methods for assessing risk in drug development, formulation technologies that avoid risk, and methods for designing and monitoring dosing in clinical practice.
Key terms
- Pharmacokinetics
- The process by which a drug that enters the body is absorbed, distributed, metabolized, and excreted
- Drug delivery system
- A mechanism that delivers a drug to where it is needed, in the amount needed
- Microfluidic device
- A small device that grows or examines cells by flowing liquid through narrow channels
- Biomarker
- A substance in the body that provides a clue to a disease or to how likely side effects are
ResearchResearch themes
The lab works on technologies to control how drugs behave in the body, evaluation systems that mimic the human body, analysis of large-scale side-effect data, and elucidation of the mechanisms of side effects.
*Illustrative imageDelivering drugs to targeted cells
The lab develops drug delivery systems that use vesicles made of lipids or synthetic polymers as drug carriers, with their surfaces decorated with molecules that recognize receptors.
*Illustrative imageEvaluating pharmacokinetics and toxicity on a chip
The lab develops systems in which cells are grown and cultured under perfusion on microfluidic devices, so that pharmacokinetics and toxicity in human tissue can be evaluated on a chip.
*Illustrative imagePredicting risk from side-effect data
The lab epidemiologically analyzes large-scale post-marketing safety data to find the characteristics of cases in which side effects occur. It comprehensively searches for drugs with hepatotoxicity and identifies biomarkers, aiming to use them for risk assessment.
*Illustrative imageMechanisms and prevention of side effects
The lab clarifies how side effects occur from the perspectives of pharmacokinetics and pharmacology. It is pursuing research related to the selection of anti-HIV drugs and analysis of the mechanism of taste disorders caused by cancer chemotherapy.
MembersFaculty
- ProfessorFumiyoshi Yamashita
- LecturerTomoko Kita
- Assistant ProfessorKanako So
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Iodine pills” Mx. Granger / CC0 (cropped)
- Delivering drugs to targeted cells: “Liposomas articulo liberación activos” Sercombe, Veerati, Moheimani, Wu, Sood and Hua / CC BY 4.0 (cropped)
- Evaluating pharmacokinetics and toxicity on a chip: “Lab-on-a-chip; Micro Microwave ( )” National Institute of Standards and Technology / Public domain (cropped)
- Predicting risk from side-effect data: “Drug Disposal ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- Mechanisms and prevention of side effects: “Ancient Apothecary Organized Shelves ( )” Richie Diesterheft from Chicago, IL, USA / CC BY-SA 2.0 (cropped)
- Related lab (Pharmacogenomics and Genomic Drug Discovery Lab): “Rasyslami” The original uploader was (Automated conversion) at English Wikipedia. / CC BY-SA 3.0 (cropped)
- Related lab (Tissue Formation Dynamics Lab): “Drosophila suzukii” Katja Schulz / CC BY 4.0 (cropped)
- Related lab (Multicellular Systems Lab): “Illu epithelium” US Government / Public domain (cropped)
- Related lab (Biomolecular Measurement Lab): “Mass spectrometer quadrupole” Fulvio314 / CC BY-SA 3.0 (cropped)
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