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Pharmaceutical Synthetic Chemistry Lab
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An organic synthesis lab that designs molecules no one has been able to make and builds them with new reactions.
AboutAbout the lab
Assembling molecules at will.
Many pharmaceuticals and biomedical materials are organic molecules, and developing new drugs and materials requires making new compounds through organic synthesis.
The Pharmaceutical Synthetic Chemistry Lab pursues organic chemistry that focuses on what kinds of molecules to design, how to synthesize them, and how to understand their properties.
The lab aims to discover and invent new methods of molecular transformation and new molecular structures that contribute to the life sciences.
Key terms
- Organic synthesis
- Artificially making carbon-containing molecules by combining chemical reactions
- Multicomponent reaction
- A reaction in which three or more starting materials react at once, forming multiple bonds together
- Ring strain
- In small-ring molecules, the state in which bonds are forced to bend, making the molecule unstable. It is the source of high reactivity
- Total synthesis
- Making complex molecules such as natural products from simple starting materials using only chemical reactions
ResearchResearch themes
The lab is particularly strong in developing new reactions that target highly reactive substances such as small rings and strained molecules, by choosing among reactive species such as anions, cations, and radicals.
*Illustrative imageBuilding complex molecules in few steps
Cascade reactions and multicomponent reactions can form multiple bonds at once. The lab develops useful methods of molecular transformation to synthesize bioactive compounds in few steps.
*Illustrative imageArtificial molecules and functional materials that work in living systems
The lab studies changes in the structures and properties of organic compounds and creates artificial molecules with functions not found in natural products. It has created a molecule that cleaves DNA only in an acidic environment.
*Illustrative imageChemistry of cyclobutanes and cyclobutenes
Molecules with a four-carbon ring have unique reactivity and three-dimensional structures derived from ring strain, but the available methods for synthesizing them are limited. Building on its own original synthetic methods, the lab works on developing next-generation organic materials.
*Illustrative imageSynthesis of bioactive natural products
Using the methodologies it has developed, the lab pursues the total synthesis of natural products and drugs with interesting biological activity. It also designs and synthesizes derivatives and analogs of natural products, aiming to create new compounds.
MembersFaculty
- ProfessorKiyosei Takasu
- LecturerYusuke Kuroda
- Assistant ProfessorAki Kohyama
- Program-Specific Assistant ProfessorTsukasa Tawatari
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Biofunctional Chemistry LabFaculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences and Department of PharmacyCreation of bioactive proteins regulating cell function and …The information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
For images provided to us or used with permission, the source is listed on each line. Wikimedia Commons images are illustrative and were not taken at the lab (they are cropped). Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Verrerie-p1030896” Rama / CC BY-SA 2.0 fr (cropped)
- Building complex molecules in few steps: “Diflomotecan synthesis (Part 2)” Mo18ekula / CC0 (cropped)
- Artificial molecules and functional materials that work in living systems: “Molecule display ( )” allispossible.org.uk / CC BY 2.0 (cropped)
- Chemistry of cyclobutanes and cyclobutenes: “Avogadro cyclobutane” NKreborn / CC BY-SA 4.0 (cropped)
- Synthesis of bioactive natural products: “Phalaenopsin La” Conan Wolff / CC0 (cropped)
- Related lab (Organic Chemistry for Drug Discovery Lab): “Chemical structure of necine bases” Xu, J., Wang, W., Yang, X., Xiong, A., Yang, L., & Wang, Z. / CC BY-SA 4.0 (cropped)
- Related lab (Pharmaceutical Molecular Chemistry Lab): “Laboratory experiment room” 薬品分子化学研究室 / 研究室からの
提供 (cropped) - Related lab (Pharmaceutical Design Lab): “Nanocapsule” GirlBossBME23 / CC BY-SA 4.0 (cropped)
- Related lab (Biofunctional Chemistry Lab): “Zinc finger rendered” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
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