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Cancer Immune Multicellular System Regulation Lab
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The lab uncovers the interplay between the immune system and cancer using data from cancer patients.
AboutAbout the lab
Exploring the science of cancer and immunity through human diversity
The lab analyzes the tumor microenvironment (the environment surrounding cancer) with its own original methods and comprehensively investigates the interactions between the immune system and cancer cells.
The lab has established the idea that genetic abnormalities in cancer cells directly affect immune responses, opening up a new field of tumor biology.
The lab approaches the mechanisms of cancer through a “from human to mouse” method: it extracts immune-related factors from comprehensive data on cancer patients and confirms their significance in mouse models.
The lab is a division of the Center for Cancer Immunotherapy and Immunobiology.
Key terms
- Tumor microenvironment
- The environment formed by immune cells, blood vessels, and other components gathered around cancer cells
- Immune surveillance
- The process by which the immune system monitors the body, detects abnormal cells such as cancer cells, and removes them
- Somatic mutation
- A change that occurs in the genes of the body's cells after birth
ResearchResearch themes
Cancer immunotherapy has shown that immune surveillance can be reactivated in humans as well, but how well it works varies between individuals. By combining immunology, genomic medicine, metabolism, and bioinformatics, the lab clarifies the mechanism that switches between a state in which the immune system holds back its attack and a state in which it keeps watch.
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MembersFaculty
- ProfessorHiroyoshi Nishikawa
- Project ProfessorTakuma Kato
- Associate ProfessorSEO Wooseok
- Program-Specific Associate ProfessorKosuke Tanaka
- Assistant ProfessorShinichiro Kato
- Program-Specific Assistant ProfessorTakashi Mikami
- Program-Specific Assistant ProfessorBARAKAT Carolyne
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Switching between immune tolerance and immune surveillance: “Dendritic cells” Haymanj / Public domain (cropped)
- Related lab (Tumor Biology (Pathology II) Lab): “Whole slide image of H&E stained breast tumour tissue” KajsaMollersen / CC BY-SA 4.0 (cropped)
- Related lab (Higher-Order Inter-System Regulation Lab): “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped)
- Related lab (Pathophysiological Biomedicine Lab): “Oxford Nanopore Technologies Mk1c” Rojoxiii / CC0 (cropped)
- Related lab (Medical Chemistry Lab): “Macrophage by NIAID” NIAID / CC BY 2.0 (cropped)
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