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Immunopharmacology Lab
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The lab aims to harness the power of the immune system for cancer treatment and skin regeneration.
AboutAbout the lab
Harnessing immunity for cancer and regenerative therapy.
The Immunopharmacology Lab aims to uncover how immune cells work and to apply that knowledge to new therapies.
Its immediate goal is to treat cancer by using the immune system. Beyond that, the lab hopes to manipulate immune cells to achieve tissue regeneration and to treat neurodegenerative diseases of the brain.
The lab seamlessly combines wet experiments with large-scale data analysis (dry), and its members come from a wide range of backgrounds.
The lab puts effort into creating an international research environment.
Key terms
- Tumor microenvironment
- The environment formed within cancer tissue by cancer cells, immune cells, blood vessels, and other components
- Prostaglandin E2
- A lipid substance produced during inflammation and in other situations. Cancer uses it to evade attack by the immune system
- Keratinocytes
- Cells that make up most of the epidermis of the skin. They differentiate to form the skin barrier
NewsLab news
Paper on a compound that promotes differentiation of skin cells published in the Journal of Pharmacological Sciences
A student received the Best Presentation Award at the Kinki Regional Meeting of the Japanese Pharmacological Society
ResearchResearch themes
By deeply understanding the immune system and the mechanisms of the diseases it aims to treat, the lab seeks to establish new therapies for diseases that currently cannot be cured. It currently focuses on two main themes: how cancer evades the immune system, and the role the immune system plays in skin regeneration.
*Illustrative imageHow cancer evades the immune system
The lab focuses on prostaglandin E2 (PGE2), an inflammatory lipid produced by cancer. It investigates how PGE2 suppresses immune function in the tumor microenvironment.
*Illustrative imageFully regenerating skin with drugs
From a pharmacological perspective, the lab explores ways to regenerate damaged skin into fully functional skin. It has found a compound that strongly promotes keratinocyte differentiation and is studying how it works.
MembersFaculty
The lab's members consist of faculty, doctoral and master's graduate students, medical students, undergraduate students, research students, and lab management staff.As of 2026
- ProfessorTHUMKEO Dean
- Assistant ProfessorSAISUWAN Krittamate
- Program-Specific Assistant ProfessorKiyoshi Toyama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Prostaglandin F2alpha 3d” Иван / Public domain (cropped)
- How cancer evades the immune system: “Tumor microenvironment” Frontiers in Oncology / CC BY 3.0 (cropped)
- Fully regenerating skin with drugs: “Melanosome distribution in keratinocytes in different skin types” Liliana Bento-Lopes, Luís C. Cabaço, João Charneca,Matilde V. Neto, Miguel C. Seabra & Duarte C. Barral / CC BY 4.0 (cropped)
- Related lab (Cancer Immunotherapy Lab): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Immune Cell Biology Lab): “Follicular helper T (Tfh) and T follicular regulatory (Tfr) cells both act in the germinal center (GC) to regulate the generation of antigen (Ag)-specific antibody-secreting cells” Xie MM and Dent AL / CC BY 4.0 (cropped)
- Related lab (Higher-Order Inter-System Regulation Lab): “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped)
- Related lab (Molecular Oncology Lab): “Oral epithelium - Epithelial cells - Methylene blue dye - View 40X” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
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