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Shiroishi Lab
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The lab studies how proteins work and creates new molecules.
AboutAbout the lab
Understanding protein function and creating new molecules
Shiroishi Lab studies the function of proteins such as drug-target receptors and antibodies, revealing it at the molecular and atomic level.
The lab gives equal importance to protein engineering, which creates new proteins, and protein science, which seeks to understand how proteins function.
Using a variety of methods from molecular biology and biophysics, the lab aims to create useful protein molecules that can contribute to human health.
The lab's website also describes it as the "Protein Engineering Lab."
Key terms
- Protein engineering
- Techniques for creating useful proteins, or for modifying proteins to stabilize them and make them easier to analyze
- Membrane protein
- A protein located in the cell membrane. Many are drug targets, but human membrane proteins are unstable and considered difficult to prepare
- Autoantibody
- An antibody that recognizes the body's own components. Rheumatoid factor recognizes the Fc region of the body's own IgG
ResearchResearch themes
Shiroishi Lab gives equal importance to protein engineering, which creates new proteins, and protein science, which seeks to understand how proteins function. Its research focuses mainly on receptors and antibodies that serve as drug targets. The lab aims to reveal their function at the molecular and atomic level and to create useful protein molecules that can contribute to human health.
*Illustrative imageCreating proteins that are easier to analyze
When analyzing the three-dimensional structure of an unstable protein, protein engineering is also useful for modifying the protein so that it is more stable and easier to analyze. Using budding yeast, the lab developed a system for rapidly producing and screening stable membrane proteins.
*Illustrative imageStructure and function of membrane receptors
More than 50% of marketed drugs and drugs under development are said to target membrane proteins. Human membrane proteins are unstable and difficult to prepare, but the lab aims to analyze their structure and function using techniques such as protein engineering.
*Illustrative imageHow antibodies recognize molecules
The lab focuses on rheumatoid factor (RF) and studies its molecular recognition mechanism. RF is an autoantibody that recognizes the Fc region of the body's own IgG.
MembersFaculty
The members of Shiroishi Lab are faculty, doctoral and master's students, and undergraduate students.As of 2026
- ProfessorMitsunori Shiroishi
- Assistant ProfessorKosuke Oyama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “FAM166C Antibody Staining” The Human Protein Atlas / CC BY-SA 3.0 (cropped)
- Creating proteins that are easier to analyze: “Bacillus anthracis - CapD protein crystal structure” Argonne National Laboratory / CC BY-SA 2.0 (cropped)
- Structure and function of membrane receptors: “Muscarinic receptor M2 coupled to protein G - 6OIK” Vcilleros / CC BY-SA 4.0 (cropped)
- How antibodies recognize molecules: “Antibody IgG1 surface” Tokenzero / CC BY-SA 4.0 (cropped)
- Related lab (吉田研究室): “Conical flask in chemistry lab” Akshaya govindasamy / CC BY-SA 4.0 (cropped)
- Related lab (西山研究室): “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (宮川研究室): “European Common Frog Rana temporaria” Richard Bartz, Munich aka Makro Freak Image:MFB.jpg / CC BY-SA 2.5 (cropped)
- Related lab (瀬木研究室): “Hippocampus - DK ATLAS” RAZVAN V. MARINESCU / CC BY 4.0 (cropped)
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