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Nishiyama Lab
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The lab explores how genes work in immune cells and how allergies arise.
AboutAbout the lab
Uncovering gene expression in immune cells
Nishiyama Lab studies how gene activity is regulated in cells involved in immunity.
Its main subjects are mast cells, which cause allergic reactions, and dendritic cells, which pass information about foreign substances to T cells.
The lab also investigates how components derived from fragrances, foods, and gut bacteria affect immune responses.
Key terms
- Mast cell
- A type of white blood cell. When it recognizes an allergen via IgE antibodies, it becomes activated and releases substances that cause sneezing and itching
- Transcription factor
- A molecule that controls gene expression. It is involved in how specific genes become active in specific cells
- Dendritic cell
- An antigen-presenting cell that responds to the invasion of pathogens by releasing cytokines and other molecules, and passes information about the invading foreign substance to T cells
NewsLab news
A paper first-authored by an Assistant Professor and a student has been accepted by Allergology International
A paper first-authored by a graduate has been accepted by International Journal of Molecular Sciences
A paper first-authored by a graduate and an Assistant Professor has been accepted by The FEBS Journal
A paper first-authored by Assistant Professors and others has been accepted by Allergology International
A paper by a student and a graduate has been accepted by Bioscience, Biotechnology, and Biochemistry
ResearchResearch themes
Nishiyama Lab studies how gene activity is regulated in immune cells involved in conditions such as allergies. Focusing on mast cells and dendritic cells, the lab also investigates how components of foods, fragrances, and gut bacteria affect immune responses.
*Illustrative imageMast cell activation and XBP1
Salicylaldehyde, an anti-allergic compound discovered in a fragrance ingredient, suppresses IgE-dependent mast cell activation, but the mechanism was unknown. Analyses using inhibitors and siRNA suggested that a pathway involving XBP1 contributes to mast cell function.
*Illustrative imageRegulation of integrin CD103 expression
The lab studied how expression of integrin CD103, which appears on mucosal-type mast cells and dendritic cells, is regulated. It found that TGF-beta acts as a positive regulator and GATA2 as a suppressor, and that the transcription factor PU.1 is involved.
*Illustrative imageGene regulation of the IL-33 decoy receptor
For IL-33, which is involved in allergic reactions, the lab studied how expression of the gene encoding the secreted decoy receptor is regulated. It has reported that regulation by the transcription factor GATA2 is common to human and mouse mast cells.
*Illustrative imageImmune-enhancing effects of a spore-forming lactic acid bacterium
The lab studied how the spore-forming lactic acid bacterium Heyndrickxia coagulans SANK70258, which is resistant to heat and acid, affects immunity. Starting from dendritic cell activation, it found activity that promotes IFN-γ secretion by NK cells and IgA production by B cells.
MembersFaculty
The members of Nishiyama Lab are faculty and doctoral, master's, and undergraduate students.As of 2026
- ProfessorChiharu Nishiyama
- Assistant ProfessorKazuki Nagata
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Mast cell activation and XBP1: “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Regulation of integrin CD103 expression: “Integrin alphaVbeta3 and RGD Binding” Lisa Zlanino / CC BY-SA 4.0 (cropped)
- Gene regulation of the IL-33 decoy receptor: “Binder CB 210 incubator interior” Shinryuu / Public domain (cropped)
- Immune-enhancing effects of a spore-forming lactic acid bacterium: “Flow Cytometer (NIH BioArt 160)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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