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Miyagawa Lab
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The lab explores sex determination and sex differentiation in animals in relation to the environment.
AboutAbout the lab
How is it decided whether an animal becomes male or female?
The Miyagawa Lab studies sex determination and sex differentiation in animals, as well as the development and differentiation of reproductive organs.
These processes are intrinsically programmed into organisms, but they are fine-tuned by various environmental factors and can sometimes change substantially.
The lab aims to elucidate these developmental programs while taking into account the influence of the environment.
In addition to model organisms such as mice and medaka, the lab also studies wild animals such as fish and reptiles.
Key terms
- Estrogen
- A type of female sex hormone. It acts on the proliferation and differentiation of cells in reproductive organs
- Endocrine-disrupting chemicals
- Chemicals that disrupt the action of hormones in the body
- Temperature-dependent sex determination
- A mechanism in which the temperature during development determines whether an animal becomes male or female
NewsLab news
A paper on transporters for serotonin and other substances in fish has been accepted by Env Sci Technol
A paper on gonad development and gene expression in the leopard gecko has been accepted by Dev Biol
A master's student received the Morita Award (poster award) at the Japan Society of Endocrine Disruptors Research
A master's student received the MBSJ Poster Award 2025 at the Annual Meeting of the Molecular Biology Society of Japan
An undergraduate student received the Excellent Poster Presentation Award at the public symposium of the Biological Fluctuation Research Division
ResearchResearch themes
The lab aims to elucidate sex determination and sex differentiation in animals, and the development and differentiation of reproductive organs, while taking into account the influence of the environment. In addition to model organisms such as mice, it also studies wild animals such as fish and reptiles.
*Illustrative imageHormones and the development and diseases of reproductive organs
The lab investigates how sex hormones act on reproductive organs, exploring the mechanisms of development and differentiation and the causes of diseases such as congenital anomalies and cancer. It analyzes the action of estrogen in tissues such as the mouse vaginal epithelium.
*Illustrative imageEffects of chemicals in the environment
The lab examines the effects of endocrine-disrupting chemicals and environmental pharmaceuticals that surround living organisms. By studying differences in responsiveness among fish species and analyzing the function of nuclear receptors, it takes a comprehensive view from the molecular level to the whole-organism level.
*Illustrative imageTemperature-dependent sex determination in reptiles
Focusing on crocodilians and turtles, the lab is working to identify the temperature-sensitive factors involved in temperature-dependent sex determination in reptiles. It aims to identify the signaling cascade (the flow in which signals are passed on one after another) inside the body.
MembersFaculty
The Miyagawa Lab consists of faculty members, master's and undergraduate students, and visiting researchers.As of 2026
- ProfessorShinichi Miyagawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “European Common Frog Rana temporaria” Richard Bartz, Munich aka Makro Freak Image:MFB.jpg / CC BY-SA 2.5 (cropped)
- Hormones and the development and diseases of reproductive organs: “Stained microscope slide” Waughd / CC BY-SA 4.0 (cropped)
- Effects of chemicals in the environment: “Puntius, a genus of small freshwater fish in the family of "Cyprinidae", captured in West Bengal, India” Billjones94 / CC BY-SA 4.0 (cropped)
- Temperature-dependent sex determination in reptiles: “Hatchlings of Batagur dhongoka and Batagur kachuga” Hari Mohan Meena / CC BY-SA 4.0 (cropped)
- Related lab (西野研究室): “Annotated Tertiary Structure of Isoform X1” BUI00059 / CC BY-SA 4.0 (cropped)
- Related lab (十島研究室): “Cell membrane 18 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (田村研究室): “TRNA 1ehz coil lots” Dcrjsr / CC BY 3.0 (cropped)
- Related lab (白石研究室): “FAM166C Antibody Staining” The Human Protein Atlas / CC BY-SA 3.0 (cropped)
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