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Toshima Lab
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A lab that explores intracellular vesicle transport, with a focus on endocytosis.
AboutAbout the lab
Exploring how cells take in and transport materials.
The Toshima Lab studies endocytosis and intracellular vesicle transport in the field of cell biology.
The lab investigates how endocytosis is controlled by the actin cytoskeleton and how the activity of G protein-coupled receptors is regulated.
The lab's website features fluorescence images of endocytosis observed in cancer-like cells.
Assistant Professor Hiroki Shimamura has used yeast to analyze the secretory pathway, through which newly synthesized proteins are transported.
Key terms
- Endocytosis
- A mechanism by which a cell takes in material from outside by wrapping it in a small membrane-bound sac and bringing it inside
- Actin cytoskeleton
- A network of fibers made of a protein called actin inside the cell. It supports the cell's shape and movement
- Vesicle transport
- A mechanism by which small membrane-bound sacs (vesicles) carry materials inside a cell
NewsLab news
A student received a Poster Award at the annual meeting of the Molecular Biology Society of Japan
A review on endocytosis was published in Subcell Biochem
A student received an Outstanding Presentation Award at the annual meeting of the Japan Radiation Research Society
ResearchResearch themes
The lab aims to gain an integrated understanding of how vesicles transport materials inside cells, with a focus on endocytosis. Its research topics also include the actin cytoskeleton, which controls endocytosis, and the regulation of G protein-coupled receptor activity.
View More ↗MembersFaculty
- ProfessorJiro Toshima
- Assistant ProfessorHiroki Shimamura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cell membrane 18 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (西野研究室): “Annotated Tertiary Structure of Isoform X1” BUI00059 / CC BY-SA 4.0 (cropped)
- Related lab (田村研究室): “TRNA 1ehz coil lots” Dcrjsr / CC BY 3.0 (cropped)
- Related lab (宮川研究室): “European Common Frog Rana temporaria” Richard Bartz, Munich aka Makro Freak Image:MFB.jpg / CC BY-SA 2.5 (cropped)
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