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Nishino Lab
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The lab explores how chromosomes work through their atomic-level three-dimensional structures.
AboutAbout the lab
Exploring the molecular world through structural biology to create the science of the future
Nishino Lab uses structural biology methods to analyze, at the atomic level, how chromosomes, the carriers of genetic information, are accurately passed on to the next generation.
Drawing on its knowledge of structural biology, the lab also works on designing proteins with new functions.
Examples of its research include structural and functional analysis of the chromosomal passenger complex, which is involved in controlling cell division, and of the kinetochore, the machinery that segregates chromosomes.
The lab also lists as research examples structural and functional analysis of the RNA silencing mechanism involved in plant antiviral defense, and the development of novel plastic-degrading enzymes.
Key terms
- Structural biology
- An approach that analyzes the three-dimensional structures of molecules such as proteins at the atomic level to study biological phenomena
- Supramolecular complex
- A large assembly of multiple proteins and other molecules. Many of the proteins that regulate chromosomes take this form
- Kinetochore
- The machinery responsible for chromosome segregation. It is one of the lab's analysis targets
NewsLab news
Structural analysis of the Ancient domain of chicken IMPACT published in Crystals
A review of the tubulin code of microtubules published in AIMS Biophysics
A study on complex formation between FANCM and MHF published in Protein Science
Structural analysis of a thermostable cutinase published in Crystals
A review on improving crystallization published in Crystals
ResearchResearch themes
Many of the proteins that regulate chromosomes form supramolecular complexes, and proteins inside the nucleus are considered difficult targets for structural biological analysis. Through functional analysis and three-dimensional structural analysis, the lab seeks to understand how chromosomes are regulated. In the future, it aims to create a new field in which chromosome-regulating complexes and chromosomes themselves can be freely manipulated.
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MembersFaculty
The members of Nishino Lab are faculty and doctoral, master's, and undergraduate students.As of 2026
- ProfessorTatsuya Nishino
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Annotated Tertiary Structure of Isoform X1” BUI00059 / CC BY-SA 4.0 (cropped)
- Structure of complexes involved in chromosome segregation: “Mitosis in Onion Root various stages (Metaphase)” Natalierussell77 / CC BY-SA 4.0 (cropped)
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- Related lab (十島研究室): “Cell membrane 18 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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