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Takasawa Lab
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The lab uses computers to design starting points for new drugs that target the mechanisms of cancer cells.
AboutAbout the lab
Searching for starting points for new drugs that target how cancer cells work
The Takasawa Lab aims to create compounds that can serve as the basis for new anticancer drugs, targeting proteins that play important roles in the survival and proliferation of cancer cells.
There is demand for drugs with a new mechanism of action that are highly effective even against cancer cells that have become resistant to anticancer drugs, and that act specifically on cancer cells.
Using in silico drug discovery methods, the lab aims to create lead compounds for molecularly targeted anticancer drugs with few side effects.
The lab also aims to develop therapeutic drugs for diseases involving abnormal regulation of apoptosis, such as cancer and Alzheimer's disease.
Key terms
- In silico drug discovery
- A method of designing and searching for candidate drug molecules through computer calculations and simulations.
- Lead compound
- A candidate compound that serves as the starting point for drug development. It is improved step by step to bring it closer to a drug.
- Apoptosis
- A mechanism by which cells kill themselves. Abnormal regulation of it is involved in diseases such as cancer.
ResearchResearch themes
The lab aims to develop therapeutic drugs for diseases involving abnormal regulation of apoptosis, such as cancer and Alzheimer's disease. Using in silico molecular design and biochemical methods, it creates apoptosis-regulating lead compounds (such as XIAP inhibitors), and for cancer, it also creates inhibitor lead compounds targeting Glyoxalase I, an enzyme involved in cancer-specific metabolism.
*Illustrative imageValidating Molecules as Targets for Cancer Therapy
The lab validates molecular targets for anticancer drug development. Its targets are proteins important for maintaining the survival and proliferation of cancer cells, such as factors involved in cancer cell-specific energy metabolism and apoptosis regulators.
Designing Candidates for New Anticancer Drugs
Using in silico drug discovery methods, the lab aims to create lead compounds for novel molecularly targeted anticancer drugs with few side effects. Drugs that are highly effective even against anticancer-drug-resistant cancer cells and that act specifically on cancer cells are needed.
MembersFaculty
- Associate ProfessorRyoko Takasawa
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Purine Nucleoside Phosphorylase” 作者不詳 / Public domain (cropped)
- Validating Molecules as Targets for Cancer Therapy: “Killer T cells surround a cancer cell” The National Institutes of Health / Public domain (cropped)
- Related lab (佐藤(聡)研究室): “Clear cell renal cell carcinoma -- intermed mag” Nephron / CC BY-SA 3.0 (cropped)
- Related lab (吉澤研究室): “Hospital room ubt” Tomasz Sienicki [user: tsca, mail: tomasz.sienicki at gmail.com] / Public domain (cropped)
- Related lab (礒濱研究室): “Blausen 0620 Lungs NormalvsInflamedAirway” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Related lab (野口研究室): “Human Respiratory Syncytial Virus (RSV) ( )” NIAID / CC BY 2.0 (cropped)
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