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Isohama Lab
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A lab that explores treatments for respiratory diseases through airway secretion and the actions of Kampo medicines.
AboutAbout the lab
Aiming for new therapeutic concepts for respiratory diseases.
To establish treatments for intractable respiratory diseases rooted in chronic inflammation, such as bronchial asthma and COPD (chronic obstructive pulmonary disease), the Isohama Lab studies how these disease conditions develop and how drugs act.
The lab focuses on searching for new target molecules to normalize airway secretion, and on clarifying the pharmacological characteristics hidden in traditional medicines such as Kampo (traditional Japanese herbal) medicines.
Aiming to develop drugs with action profiles different from existing ones, the lab works on creating drugs that regulate the function of aquaporins and drugs that suppress airway mucus secretion.
Key terms
- Aquaporin
- A water channel protein in the cell membrane. Besides its role in water balance throughout the body, it is also involved in cell proliferation and inflammatory responses
- Airway mucus
- Mucus produced in the airways, commonly known as sputum. In almost all chronic respiratory diseases, its excessive production and secretion is a problem
- Crude drugs
- Natural medicinal materials, such as plants, that are used as raw materials for Kampo medicines. This lab uses them as research samples
ResearchResearch themes
Aiming to develop drugs with action profiles different from existing ones, the lab pursues research from two perspectives: creating drugs that regulate the activity and expression of aquaporins, and creating drugs that suppress airway mucus secretion.
*Illustrative imageDrugs that regulate aquaporins
The lab searches for drugs that regulate the function or expression of aquaporins. It has found effects such as inhibition of water channel function in crude drug extracts and their components, and aims to apply these to anti-edema drugs, anti-inflammatory drugs, and drugs that promote wound healing.
*Illustrative imageDrugs that suppress airway mucus secretion
In almost all chronic respiratory diseases, excessive production and secretion of sputum (airway mucus) is a problem. Aiming to create drugs that suppress mucus production, the lab evaluates the effects of drugs in a variety of in vitro and in vivo experimental systems.
MembersFaculty
- ProfessorYoichiro Isohama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blausen 0620 Lungs NormalvsInflamedAirway” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Drugs that regulate aquaporins: “2625 Aquaporin Water Channel” OpenStax College / CC BY 3.0 (cropped)
- Drugs that suppress airway mucus secretion: “Asthma Inhaler ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (佐藤(聡)研究室): “Clear cell renal cell carcinoma -- intermed mag” Nephron / CC BY-SA 3.0 (cropped)
- Related lab (吉澤研究室): “Hospital room ubt” Tomasz Sienicki [user: tsca, mail: tomasz.sienicki at gmail.com] / Public domain (cropped)
- Related lab (野口研究室): “Human Respiratory Syncytial Virus (RSV) ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (髙澤研究室): “Purine Nucleoside Phosphorylase” 作者不詳 / Public domain (cropped)
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