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Sato (Satoshi) Lab
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A lab aiming to develop treatments for cancer and other diseases by studying cell death and resistance to anticancer drugs.
AboutAbout the lab
Studying cell death to lead to treatments for cancer, retinal degenerative diseases, and more
The Sato (Satoshi) Lab studies the processes that determine whether cells live or die, and the mechanisms of drug resistance in cancer.
Founded in April 2018, it is a small lab that takes advantage of its agility in its research.
The lab aims to understand how cancer cells die and how they become resistant to anticancer drugs, and to connect this to cancer treatment.
It also investigates the modes and mechanisms of retinal cell death, with the goal of protecting retinal cells and controlling cell death.
Key terms
- Necrosis
- One of the major categories of cell death, classified by morphological and biochemical features
- Apoptosis
- The other major category of cell death alongside necrosis. It is also a type of cell death that occurs with anticancer drugs
- Retinal pigment epithelial cells
- Cells in the retina. When they are damaged and die, they can cause retinal degenerative diseases such as age-related macular degeneration
- Omics analysis
- A general term for analytical technologies that comprehensively examine genes, RNA, proteins, and so on
NewsLab news
Paper on colorectal cancer cells resistant to a PARG inhibitor published in FEBS Open Bio
Master's student receives an excellence award at a symposium of the Research Division on Fluctuations in Life
Paper from joint research with Morinaga & Co., Ltd. published in Scientific Reports
Paper on 3D culture of 5-FU-resistant colorectal cancer cells published in Nucleosides, Nucleotides & Nucleic Acids
Paper on temozolomide-resistant glioblastoma published in Nucleosides, Nucleotides & Nucleic Acids
ResearchResearch themes
The lab aims to understand how cancer cells die and become resistant to anticancer drugs, identify new molecular targets for cancer, and develop cancer therapies using nucleic acids or small-molecule compounds. It also studies the mechanisms of retinal pigment epithelial cell death, aiming to build therapeutic strategies that protect retinal cells.
*Illustrative imageCancer cell death and anticancer drug resistance
The lab studies the mechanisms of necrosis and apoptosis that anticancer drugs induce in cancer cells, and how cancer cells acquire resistance. It aims to find new molecular targets for cancer and develop therapies using nucleic acids or small-molecule compounds.
*Illustrative imageRetinal cell death and protection
Injury and death of retinal pigment epithelial cells cause retinal degenerative diseases such as age-related macular degeneration. The lab aims to understand the modes and mechanisms of cell death and build therapeutic strategies that protect retinal cells or control cell death.
*Illustrative imageFinding target molecules with omics analysis
Using omics analyses such as exome sequencing, RNA sequencing, and proteomics, the lab comprehensively examines mutations and expression of genes, RNA, and proteins. It extracts candidate target molecules through bioinformatics and analyzes their functions using biochemical and molecular biology methods.
MembersFaculty
The members of the Sato (Satoshi) Lab are faculty members, doctoral students (in the second-stage doctoral program and the doctoral program), and undergraduate students.As of 2026
- Associate ProfessorAkira Sato
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Clear cell renal cell carcinoma -- intermed mag” Nephron / CC BY-SA 3.0 (cropped)
- Cancer cell death and anticancer drug resistance: “Chemotherapy vials (4)” Bill Branson (Photographer) / Public domain (cropped)
- Retinal cell death and protection: “Fundus photograph of normal right eye” Mikael Häggström. When using this image in external works, it may be cited as: Häggström, Mikael (2014). "Medical gallery of Mikael Häggström 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.008. ISSN . Public Domain. or By Mikael Häggström, used with permission. / CC0 (cropped)
- Finding target molecules with omics analysis: “Protein pattern analyzer” 作者不詳 / Public domain (cropped)
- Related lab (吉澤研究室): “Hospital room ubt” Tomasz Sienicki [user: tsca, mail: tomasz.sienicki at gmail.com] / Public domain (cropped)
- Related lab (礒濱研究室): “Blausen 0620 Lungs NormalvsInflamedAirway” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Related lab (野口研究室): “Human Respiratory Syncytial Virus (RSV) ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (髙澤研究室): “Purine Nucleoside Phosphorylase” 作者不詳 / Public domain (cropped)
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