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Higami Lab
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The lab explores the mechanisms of aging and obesity through the functions of adipose tissue.
AboutAbout the lab
Understanding aging and obesity through adipose tissue
The Molecular Pathology and Metabolism Lab studies the mechanisms of aging and obesity from the functions of adipose tissue and adipocytes.
Using long-lived mice and obese mice, the lab analyzes the functions of adipose tissue and adipocytes, as well as mitochondrial function.
The lab is searching for drug discovery seeds for anti-obesity drugs and metabolism-improving drugs that can prevent the various diseases that develop with aging and also extend healthy life expectancy.
Key terms
- Calorie restriction
- Moderately limiting caloric intake. Studies in monkeys suggest it has anti-aging and lifespan-extending effects
- Autophagy
- A mechanism in which aged organelles and unneeded proteins in a cell are enclosed in a membrane and broken down by enzymes in lysosomes
- Mitochondria
- One of the organelles in cells. This lab studies their function in adipocytes
ResearchResearch themes
The lab is searching for seeds that could lead to drugs that prevent the various diseases that develop with aging and can also extend healthy life expectancy. To this end, it uses long-lived mice and obese mice to analyze the functions of adipose tissue, adipocytes, and mitochondria.
*Illustrative imageAnalysis of adipose tissue in long-lived mice
The lab investigates how calorie restriction extends lifespan, focusing on adipose tissue. Exploring mechanisms that do not depend on the action of growth hormone, it found that the reaction in which fatty acids are made from sugar in adipose tissue is important.
*Illustrative imageAutophagy impairment in the adipose tissue of obesity
The lab examines whether autophagy and lysosomal function are impaired in the adipose tissue of obesity. It has shown that abnormal activity of cathepsin, a degradative enzyme, is linked to impaired autophagy and abnormal lipid breakdown.
*Illustrative imageMitochondrial function in adipocytes
The lab studied the effect on adipocyte mitochondria of the tumor suppressor gene TP53, which increases in the adipose tissue of obesity, and showed that it is a factor that suppresses mitochondrial biogenesis. It also identified WWP1, whose expression is regulated by TP53, and is studying its function in knockout mice.
MembersFaculty
- ProfessorYoshikazu Higami
- LecturerYuhei Mizunoe
- LecturerYuka Nozaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Brown fat cell” https://www.scientificanimations.com/ / CC BY-SA 4.0 (cropped)
- Analysis of adipose tissue in long-lived mice: “Marrow Adipose Tissue (typical quantity young mouse) cropped” File:Marrow Adipose Tissue (typical quantity young mouse) .jpg: Mstyner derivative work: Guanaco / CC BY-SA 4.0 (cropped)
- Autophagy impairment in the adipose tissue of obesity: “Binder CB 210 incubator interior” Shinryuu / Public domain (cropped)
- Mitochondrial function in adipocytes: “Mitochondria 7 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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