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Hayata Lab
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The lab explores how organs are formed and what causes intractable diseases, using mouse genetics and genome editing.
AboutAbout the lab
Elucidating the molecular mechanisms that control organ formation
The Hayata Lab studies the basic molecular and cellular principles behind the development, differentiation, maintenance of homeostasis, and repair of the various types of cells that build the body's organs.
Using mouse genetics, genome editing technology, omics analysis, and regenerative medicine approaches, the lab investigates how organs such as the musculoskeletal system and kidneys are formed.
The lab aims to contribute to the development of new drugs and preventive and therapeutic methods for intractable diseases.
It is a lab in the field of Molecular Pharmacology in the Department of Life Sciences and Drug Discovery, Faculty of Pharmaceutical Sciences.
Key terms
- Genome editing
- Technology for rewriting targeted parts of genes (DNA)
- Omics analysis
- Analysis that comprehensively examines the molecules inside cells, such as genes and proteins
- Osteoclasts
- Cells that resorb bone and remodel it. Together with osteoblasts, which build bone, they are responsible for bone metabolism
ResearchResearch themes
The lab aims to explore the basic molecular and cellular principles involved in the development, differentiation, maintenance of homeostasis, and repair of the various cells that make up organs. Using mouse genetics, genome editing technology, omics analysis, and regenerative medicine approaches, it investigates how organs such as the musculoskeletal system and kidneys are formed.
*Illustrative imageHow organs are formed and how diseases arise
The research themes include elucidating the mechanisms of organ formation, pathophysiological analysis of muscle, skeletal, and kidney diseases, and elucidating the mechanisms of action of drugs used to treat diseases. The lab aims to gain a deep understanding of how organs are formed and to apply it to the development of new drugs and preventive and therapeutic methods for intractable diseases.
*Illustrative imageBone and cartilage cells and their drug responses
With a view to contributing to the development of treatments for osteoporosis, knee osteoarthritis, rheumatoid arthritis, congenital skeletal dysplasias, and other conditions, the lab studies how osteoblasts, osteoclasts, and chondrocytes respond to drugs.
MembersFaculty
- ProfessorTadayoshi Hayata
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mouse embryonic salivary gland growing in vitro” Irebustini / CC BY 4.0 (cropped)
- How organs are formed and how diseases arise: “Echinoderm embryo undergoing second cleavage” Bruno C. Vellutini / CC BY-SA 4.0 (cropped)
- Bone and cartilage cells and their drug responses: “Cartilage from mouse joint” Kevin Mackenzie, University of Aberdeen / CC BY 4.0 (cropped)
- Related lab (内海研究室): “DNA Double Helix by NHGRI” National Human Genome Research Institute / Public domain (cropped)
- Related lab (原田研究室): “T Lymphocyte ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (秋本研究室): “BS-Fig1” Goodwin G. Jinesh / CC BY-SA 4.0 (cropped)
- Related lab (秋田研究室): “Pick and Inhaler, Any Inahler” Alan Levine / CC BY 2.0 (cropped)
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