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Uchiro Lab
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A lab that designs and synthesizes new drugs modeled on natural products.
AboutAbout the lab
Creating new drugs, guided by natural products.
The Uchiro Lab studies the design and synthesis of compounds, based on naturally occurring bioactive substances, that could lead to new drugs.
The lab investigates the structure-activity relationships of bioactive substances, aiming for compounds that act more selectively and potently on their target biomolecules.
Through these challenges, the lab also works on developing new synthetic reactions.
Key terms
- Bioactive substance
- A substance that has some effect inside a living organism. It can be a starting point for developing drugs.
- Asymmetric total synthesis
- A method of building a target molecule from starting materials through a series of chemical reactions, controlling even its three-dimensional shape as intended.
- Enzyme inhibitor
- A compound that suppresses the action of enzymes in the body.
ResearchResearch themes
The lab investigates the structure-activity relationships of bioactive substances, aiming to gain clues for creating new drugs. Listed research topics include the asymmetric total synthesis of naturally occurring bioactive substances, the development of new methods for constructing highly strained cyclic ether structures, and the molecular design and synthesis of new enzyme inhibitors using computational science.
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MembersFaculty
- ProfessorHiromi Uchiro
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Inside the Medicinal Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Designing and Synthesizing Drugs Guided by Natural Products: “Inside the Medicinal Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
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- Related lab (横山研究室): “CSIRO ScienceImage 1304 Protein crystals” division, CSIRO / CC BY 3.0 (cropped)
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