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Wada-Sato Lab
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A lab working on drug discovery through the chemistry of nucleic acids, sugars, and peptides.
AboutAbout the lab
Creating nucleic acids, sugars, and peptides through chemistry
The Wada-Sato Lab conducts research in nucleic acid chemistry, carbohydrate chemistry, and peptide chemistry.
The lab researches the creation of nucleic acid drugs using organic chemistry methods, and the chemical modification of biomolecules such as sugars and peptides to create new functional molecules and drugs.
Lecturer Kazuki Sato works on the chemical synthesis of sugar phosphates, phosphorus-modified nucleic acids, and peptides.
Key terms
- Sugar phosphate
- A compound in which phosphate is bound to a sugar. It is one of the molecules handled in carbohydrate chemistry.
- Phosphorus-modified nucleic acid
- A molecule in which the phosphorus portion of a nucleic acid has been chemically altered.
- Nucleic acid drug
- A drug that uses molecules close to DNA or RNA. It is expected to be the next generation of drugs after small-molecule drugs and antibody drugs.
- DDS
- Drug delivery system. Technology for delivering a drug to its target site in the body.
NewsLab news
Lecturer Kazuki Sato received the Encouragement Award of the Japanese Society of Carbohydrate Research.
Lecturer Kazuki Sato received the Encouragement Award of the Japanese Society of Nucleic Acids Medicine.
Lecturer Kazuki Sato received the Encouragement Award of the Tokyo Glycoscience Research Meeting (GlycoTokyo).
ResearchResearch themes
The Wada-Sato Lab works on creating drugs and functional molecules through organic chemistry methods in the fields of nucleic acid chemistry, carbohydrate chemistry, and peptide chemistry. Lecturer Kazuki Sato continues research on the chemical synthesis of sugar phosphates, phosphorus-modified nucleic acids, and peptides.
*Illustrative imageDeveloping Therapeutics from Sugar Phosphate Derivatives
Lecturer Kazuki Sato prepares sugar 1-phosphate derivatives with controlled stereochemistry at the phosphorus atom, aiming to develop a treatment for leishmaniasis.
*Illustrative imageSynthesis and Pharmaceutical Applications of Phosphorus-Modified Nucleic Acids
The lab researches stereoselective synthetic methods for nucleic acids modified at the phosphorus atom, and their application to drugs.
*Illustrative imageSynthesis and Pharmaceutical Applications of Artificial Oligosaccharides
The lab synthesizes artificial oligosaccharides capable of molecular recognition and works on applying them to drugs.
*Illustrative imageArtificial Peptides That Bind Nucleic Acids
The lab synthesizes artificial peptides that bind nucleic acids and works on applying them to drug delivery systems (DDS).
MembersFaculty
- ProfessorTakeshi Wada
- LecturerKazuki Sato
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Liberty Blue CEM” Chrumps / CC BY-SA 4.0 (cropped)
- Developing Therapeutics from Sugar Phosphate Derivatives: “Crystallized sugar, multiple crystals and a single crystal grown from seed” Zaereth / CC BY-SA 4.0 (cropped)
- Synthesis and Pharmaceutical Applications of Phosphorus-Modified Nucleic Acids: “DNA-fragment-3D-vdW” 作者不詳 / Public domain (cropped)
- Synthesis and Pharmaceutical Applications of Artificial Oligosaccharides: “Branch Oligosaccharide Abbreviated” Ccostell / Public domain (cropped)
- Artificial Peptides That Bind Nucleic Acids: “CSIRO ScienceImage 1117 Close up of peptide modelled into beta binding site” division, CSIRO / CC BY 3.0 (cropped)
- Related lab (
青木研究室): “Lab Mol Colloidal quantum dots 01” Lab mol (Ilia Litvinov) / CC BY 4.0 (cropped) - Related lab (草森研究室): “Line of culture flask ( )” Jean-Etienne Minh-Duy Poirrier from USA / CC BY-SA 2.0 (cropped)
- Related lab (内呂研究室): “Inside the Medicinal Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Related lab (横山研究室): “CSIRO ScienceImage 1304 Protein crystals” division, CSIRO / CC BY 3.0 (cropped)
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