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Yokoyama Lab
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A lab that aims to design drugs based on the three-dimensional structures of proteins.
AboutAbout the lab
Designing drugs from the shapes of proteins
The Yokoyama Lab studies the three-dimensional structures of disease-related proteins and other proteins in order to clarify how they function.
The lab also targets proteins that are drug discovery targets, and determines their structures by X-ray crystallography.
It also determines the structures of complexes between a protein and a compound (drug) that regulates its function, and aims to design compounds that regulate protein function more efficiently (drug design).
Key terms
- X-ray crystallography
- A method for determining the three-dimensional structure of a protein. The lab uses it to determine the structures of disease-related proteins and other proteins
- Drug design
- Designing compounds (drugs) that regulate protein function so that they work more efficiently
- Kinesin
- A motor protein that acts specifically during the mitotic phase of cell division. The lab analyzes the structures of its complexes with inhibitors
ResearchResearch themes
Proteins show appropriate functions by adopting appropriate structures. The lab determines the structures of disease-related proteins and proteins that are drug discovery targets, and aims to design compounds that regulate their functions.
*Illustrative imageFrom protein structures to drug design
The lab determines the three-dimensional structures of disease-related proteins and proteins that are drug discovery targets by X-ray crystallography, and clarifies their functions. It also determines the structures of complexes with drugs, and aims to design compounds that regulate protein function (drug design).
*Illustrative imageStructural analysis of kinesin–inhibitor complexes
The lab is carrying out structural analysis of complexes between kinesin, a motor protein specific to the mitotic phase of cell division, and its inhibitors. Based on the structures obtained, it aims to design new anticancer drugs.
MembersFaculty
- ProfessorHideshi Yokoyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “CSIRO ScienceImage 1304 Protein crystals” division, CSIRO / CC BY 3.0 (cropped)
- From protein structures to drug design: “Protein Structure of human NDNF” Alpha Fold Team / CC BY 4.0 (cropped)
- Structural analysis of kinesin–inhibitor complexes: “Protein KIFC3 PDB 2h58” Emw / CC BY-SA 3.0 (cropped)
- Related lab (内海研究室): “DNA Double Helix by NHGRI” National Human Genome Research Institute / Public domain (cropped)
- Related lab (原田研究室): “T Lymphocyte ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (秋本研究室): “BS-Fig1” Goodwin G. Jinesh / CC BY-SA 4.0 (cropped)
- Related lab (内呂研究室): “Inside the Medicinal Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
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