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Pathophysiology and Pathology Lab
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The lab studies under the microscope how cancer spreads.
AboutAbout the lab
Three pillars: pathology research, diagnosis, and education.
The lab is built on three pillars: basic research in pathology, pathological diagnosis, and student education.
In its basic research, the lab investigates how malignant tumors of the digestive organs spread and how tumor cells undergo transdifferentiation.
The lab performs pathological diagnosis in the Pathology Division of Chiba University Hospital, and also carries out autopsies in cooperation with the Tumor Pathology Lab and the Diagnostic Pathology Lab.
The lab strives to give lectures that make medical students and graduate students interested in pathology, and supervises many students in their presentations at the Japanese Society of Pathology.
Key terms
- Transdifferentiation
- The process in which a cell that has developed into one type takes on the characteristics of a different cell type
- Invasion
- The spread of tumor cells by infiltrating the surrounding normal tissue
- Precancerous lesion
- A change in tissue at the stage just before it becomes cancer
NewsLab news
View More ↗ResearchResearch themes
The lab investigates how malignant tumors of the digestive organs spread and metastasize, and how tumor cells undergo transdifferentiation. For pancreatic cancer, which has a poor prognosis, it also conducts clinicopathological research aimed at stratified treatment.
*Illustrative imageAFP-Producing Adenocarcinoma
AFP is a plasma protein produced during the fetal period, but it is occasionally produced by adenocarcinomas, and such adenocarcinomas have an extremely poor prognosis. Believing that transdifferentiation of glandular epithelial cells into hepatocytes is involved in their development, the lab is searching for new therapeutic targets.
*Illustrative imageInvasion and Metastasis of Malignant Tumors
The lab investigates the mechanisms by which invasive pancreatic ductal carcinoma and colorectal tubular adenocarcinoma infiltrate surrounding tissue and metastasize. It focuses on changes in protein expression in tumor cells at the invasive front, and on the influence they receive from the surrounding stroma.
*Illustrative imageClinicopathological Research on Pancreatic Cancer
Pancreatic cancer has the worst prognosis among malignant tumors of the digestive organs. By examining the histology of many surgically resected specimens in detail under the microscope, the lab studies new features of pancreatic cancer, precancerous lesions, and the underlying genetic abnormalities, aiming for stratified treatment.
MembersFaculty
The members of the Pathophysiology and Pathology Lab consist of faculty, technical staff, and administrative assistants.
- Associate ProfessorTakashi Kishimoto
- Assistant ProfessorYusuke Kochi
- Assistant ProfessorSakurako Kagitani
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Charity Hospital Pathology Dept 1889 NOLA” Photographer not credited / Public domain (cropped)
- AFP-Producing Adenocarcinoma: “Histopathology of tubular carcinoma, low magnification” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D. / CC0 (cropped)
- Invasion and Metastasis of Malignant Tumors: “Histopathology of invasive ductal carcinoma, intermediate magnification” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Clinicopathological Research on Pancreatic Cancer: “Adenocarcinoma of Pancreas, FNA ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (Diagnostic Pathology Lab): “Pathology department at the central cancer research laboratories” Unknown photographer / Public domain (cropped)
- Related lab (Clinical Oncology Lab): “Chemotherapy drug” Larry Ostby (Photographer) / Public domain (cropped)
- Related lab (Public Health Lab): “DNBSEQ-G400” RPSkokie / CC BY-SA 4.0 (cropped)
- Related lab (Advanced Applied Surgery Lab): “Laparoscopic surgery in Afghanistan 141130-N-JY715-518” Lt.Cmdr. Jesse Ehrenfeld / Public domain (cropped)
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